| Gene Symbol | CDK12 |
| Full Name | Cyclin-Dependent Kinase 12 |
| Protein Type | Kinase |
| Function | CDK12 is a serine/threonine kinase that forms a complex with cyclin K to phosphorylate the C-terminal domain (CTD) of RNA polymerase II. |
| Primary Expression | all CA regions
- Motor Cortex: High expression in upper motor neurons
- Spinal Cord: Present in motor neurons
- Cerebellum: Moderate expre |
| Molecular Weight | 164 kDa |
| Pathways | Autophagy, Epigenetic |
| Ensembl ID | ENSG00000167258 |
| GeneCards | CDK12 |
| Human Protein Atlas | CDK12 |
| Kinase Domain | C-terminal serine/threonine kinase domain |
| Cyclin-Binding Region | N-terminal region for cyclin K interaction |
| RS-Rich Region | Arginine-serine rich region involved in RNA processing |
| Associated Diseases | PULMONARY_FUNCTION |
| Interactions | ATG3, ATG7, CDK4, ATG16L1, LC3, CANCER |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |