gene

ATG3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

252Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 190 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG3
Full Name	Autophagy Related 3
Chromosome	3q13.11
Function	is an essential autophagy gene encoding a ubiquitin-like conjugating enzyme that plays a critical role in autophagosome formation[@mizushima2011].
Molecular Weight	~35 kDa
Amino Acids	314 amino acids
Exons	12
Pathways	Apoptosis, Autophagy, Car-T, Immunotherapy, Tdp-43
GeneCards	ATG3
Human Protein Atlas	ATG3
Feature	Details
Genomic Coordinates	GRCh38: Chr3:112,456,789-112,501,234
Gene Length	~45 kb
mRNA Variants	4 major isoforms
Protein Length	314 amino acids
Associated Diseases	ALS, Inflammation, Ms, Osteoarthritis, Rheumatoid Arthritis
Interactions	NCOA4, RAB7A, ATG4B, CAT, TARDBP, ATG7
KG Connections	252 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG3["ATG3"] -->|"protects against"| CD19_CAR_T_cell_cytotoxicity["CD19 CAR-T cell cytotoxicity"]
    ATG3["ATG3"] -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ATG3["ATG3"] -->|"therapeutic target"| Als["Als"]
    ATG3["ATG3"] -->|"activates"| Cancer["Cancer"]
    ATG3["ATG3"] -->|"regulates"| Leukemia["Leukemia"]
    ATG3["ATG3"] -->|"regulates"| Cancer_1["Cancer"]
    CAT["CAT"] -->|"therapeutic target"| ATG3["ATG3"]
    ATG4B["ATG4B"] -->|"therapeutic target"| ATG3["ATG3"]
    TARDBP["TARDBP"] -->|"therapeutic target"| ATG3["ATG3"]
    ATG13["ATG13"] -->|"contributes to"| ATG3["ATG3"]
    style ATG3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (162)

Target	Relation	Type	Str
CD19 CAR-T cell cytotoxicity	protects_against	phenotype	0.90
Ferroptosis	contributes_to	process	0.85
autophagy pathway	participates_in	pathway	0.80
ATG7	inhibits	gene	0.70
Autophagy	regulates	pathway	0.70
Autophagy	expressed_in	pathway	0.70
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Leukemia	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Osteoarthritis	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Pain	therapeutic_target	disease	0.65
FERROPTOSIS	contributes_to	phenotype	0.64
ATG4B	therapeutic_target	gene	0.60
TARDBP	therapeutic_target	gene	0.60
CAT	therapeutic_target	gene	0.60
ATG7	contributes_to	gene	0.60
ATG13	contributes_to	gene	0.60
ATG4B	contributes_to	gene	0.60
NCOA4	activates	gene	0.60
RAB7A	activates	gene	0.60
BECN1	contributes_to	gene	0.60
IRF1	regulates	gene	0.60
TNF	regulates	gene	0.60
STAT1	regulates	gene	0.60
RB1CC1	regulates	gene	0.60
TNFR1	regulates	gene	0.60
CD19	regulates	gene	0.60
BECN1	regulates	gene	0.60
ATG4B	inhibits	gene	0.60
CAT	inhibits	gene	0.60
TARDBP	inhibits	gene	0.60
ATG5	contributes_to	gene	0.60

Incoming (90)

Source	Relation	Type	Str
AUTOPHAGY	regulates	gene	0.70
GENES	regulates	gene	0.70
AUTOPHAGY	expressed_in	gene	0.70
LC3B	expressed_in	gene	0.70
CAT	therapeutic_target	gene	0.60
ATG4B	therapeutic_target	gene	0.60
TARDBP	therapeutic_target	gene	0.60
ATG13	contributes_to	gene	0.60
ATG5	contributes_to	gene	0.60
BECN1	contributes_to	gene	0.60
NCOA4	activates	gene	0.60
ATG7	contributes_to	gene	0.60
RAB7A	activates	gene	0.60
ATG4B	contributes_to	gene	0.60
CYCS	associated_with	gene	0.60
SOD1	inhibits	gene	0.60
P62	inhibits	gene	0.60
UBC	associated_with	gene	0.60
MTOR	activates	gene	0.60
ATG12	regulates	gene	0.60
EIF2A	activates	gene	0.60
CAT	regulates	gene	0.60
FGF18	expressed_in	gene	0.60
BECLIN1	expressed_in	gene	0.60
BECN1	associated_with	gene	0.60
CD19	regulates	gene	0.60
TNF	regulates	gene	0.60
BECN1	regulates	gene	0.60
BECLIN1	associated_with	gene	0.60
ATG9A	activates	gene	0.60
ARAF	activates	gene	0.60
BECLIN1	activates	gene	0.60
ATG12	activates	gene	0.60
MYC	activates	gene	0.60
CDK12	activates	gene	0.60
ATG4B	regulates	gene	0.60
TARDBP	regulates	gene	0.60
RB1CC1	regulates	gene	0.60
TNFR1	regulates	gene	0.60
STAT1	regulates	gene	0.60
IRF1	regulates	gene	0.60
BECN1	expressed_in	gene	0.60
ATG5	expressed_in	gene	0.60
SQSTM1	expressed_in	gene	0.60
LAMP1	expressed_in	gene	0.60
ATG16L1	expressed_in	gene	0.60
WIPI2	expressed_in	gene	0.60
CD68	expressed_in	gene	0.60
MBP	expressed_in	gene	0.60
LC3	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG3

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG3 Gene

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

MAP1LC3A Gene

Autophagy-Lysosomal Pathway

Mitophagy

Autophagy Types in Neurodegeneration

herc5

ATG7 Protein — Autophagy-Related Protein 7

CBS Autophagy-Lysosomal Pathway Dysfunction

ATG4D Gene

WIPI1 Gene

ATG4B — Autophagy Related 4B Cysteine Peptidase

Autophagy Molecular Regulation in Neurodegeneration

ATG9L1 (Autophagy Related 9 Like 1)

Lipophagy Activation Therapy for Neurodegeneration

GABARAP Protein

ATG7 Protein

ATG4C Gene