protein 1,094 words KG: ARAF 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

A-Raf Protein

🔬 Protein Info
Gene SymbolARAF
Protein FamilyRAF family, MAP3K
Protein TypeKinase
Functionis a serine/threonine protein kinase belonging to the RAF family (along with BRAF and RAF1/C-Raf).
Primary ExpressionUbiquitous, highest in brain, heart, lung
Molecular Weight67 kDa
Amino Acids606 aa
PathwaysMAPK, MAPK pathway
UniProt ID[P04003](https://www.uniprot.org/uniprot/P04003)
Ensembl IDENSG00000078061
GeneCardsARAF
Human Protein AtlasARAF
Associated Diseasesneurodegeneration
InteractionsBECLIN1, ATG12, MYC, CDK12, ATG3, ATG7
KG Connections23 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Membrane Cholesterol Gradient Modulators
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: activates
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: implicated_in
MYC Gene
gene · KG edge: activates
MAP1LC3A Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ARAF activates BECLIN1
ARAF activates ATG12
ARAF activates MYC
ARAF activates CDK12
ARAF activates ATG3
ARAF activates ATG7
ARAF activates CDK4
ARAF activates ATG16L1
ARAF activates LC3
ARAF implicated_in ERK1