gene 1,076 words KG: BCHE
Contents

BCHE Gene - Butyrylcholinesterase

🧬 Gene Info
Gene SymbolBCHE
AliasesPage for BCHE Gene
Chromosome3q26.1
Protein TypeHydrolase
FunctionUnlike acetylcholinesterase (AChE), which is primarily localized at neuronal synapses, BuChE is found in: - Plasma — the major source of circulating BuChE - Liver — primary site of synthesis - Brain —
Primary ExpressionLiver, Brain (cerebral cortex, hippocampus, basal forebrain), Serum
Subcellular Localizationneuronal synapses, BuChE is found in:
Amino Acids574 aa
Exons4
Pathwaysautophagy pathway
UniProt IDP06276
NCBI Gene ID163
Ensembl IDENSG00000114200
OMIM177400
GeneCardsBCHE
Human Protein AtlasBCHE
Associated DiseasesAlzheimer, Alzheimer's disease, Anxiety, Dementia, Depression
Known Drugs/Compoundsantidementia drugs
InteractionsA2M, ACHE, ALZHEIMER, ALZHEIMER'S DISEASE, APOE, APOE4
KG Connections153 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66

Related Analyses (4)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with
ACE Gene
gene · KG edge: transports
ADRA2A Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAOB associated_with BCHE
GABRA1 associated_with BCHE
CHAT associated_with BCHE
CYP2D6 associated_with BCHE
APOE associated_with BCHE
HMGCR associated_with BCHE
OPRM1 associated_with BCHE
SLC30A8 associated_with BCHE
COMT associated_with BCHE
NBEA associated_with BCHE

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