Contents

SLC30A8 Gene

🧬 Gene Info

Gene Symbol	SLC30A8
Protein Type	Transporter
Function	SLC30A8 encodes ZnT-8 (Zinc Transporter 8), a member of the SLC30 family of zinc transporters that facilitate zinc efflux from cells [@chimienti2004].
Subcellular Localization	Insulin Granules: Primary localization in pancreatic beta cells
Pathways	Epigenetic, autophagy pathway
Ensembl ID	ENSG00000137336
GeneCards	SLC30A8
Human Protein Atlas	SLC30A8
Pancreatic Beta Cells	Mediates zinc transport into insulin secretory granules [@emdin1980]
Zinc Homeostasis	Maintains cellular zinc balance
Insulin Crystallization	Zinc is essential for insulin hexamer formation and storage [@dunn2005]
Glucose-Stimulated Insulin Secretion	Critical for proper insulin secretion [@rutter2014]
Six Transmembrane Domains	Characteristic of SLC30 family
Intracellular N- and C-termini	Regulatory domains
Histidine-Rich Loop	Zinc binding and transport regulation
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety, Dementia
Interactions	GENES, PER
KG Connections	82 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph