gene 734 words KG: MAOB 2026-03-21
kind:genesection:genesstate:published
Contents

MAOB Gene

🧬 Gene Info
Gene SymbolMAOB
Full NameMonoamine Oxidase B
ChromosomeXp11.23
Protein FamilyMonoamine oxidase family
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionplatelets and in the mitochondrial outer membrane of serotonergic and dopaminergic neurons
Molecular Weight58.7 kDa
Pathwaysautophagy pathway
UniProt IDP50395
NCBI Gene ID4129
Ensembl IDENSG00000105707
OMIM309860
GeneCardsMAOB
Human Protein AtlasMAOB
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
InteractionsIL1B, CASP3, APP, GSK3B, TNF, MICRORNAS
KG Connections161 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
BDNF Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

MAOB associated_with GABRA1
MAOB associated_with CHAT
MAOB associated_with CYP2D6
MAOB associated_with APOE
MAOB associated_with HMGCR
MAOB associated_with OPRM1
MAOB associated_with SLC30A8
MAOB associated_with COMT
MAOB associated_with NBEA
MAOB associated_with HTR2C