gene 673 words KG: EIF2S1 2026-03-22
kind:genesection:genesstate:published
Contents

EIF2S1 (eIF2α)

🧬 Gene Info
Gene SymbolEIF2S1
FunctionThe eIF2·GTP·Met-tRNAi ternary complex is essential for every round of translation initiation.
PathwaysAutophagy, Er Stress, Unfolded Protein Response
Ensembl IDENSG00000134001
GeneCardsEIF2S1
Human Protein AtlasEIF2S1
Associated DiseasesAD, ALI, Als, Cardiovascular, Ischemia, Ms
InteractionsRIPK3, DRP1, CHOP, BECN1, PTEN, DDIT3
KG Connections468 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Mitochondrial Transfer Pathway Enhancement
Score: 0.44
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

EIF2S1 activates PGAM5
EIF2S1 activates RIP3
EIF2S1 activates RETREG1
EIF2S1 activates disease
EIF2S1 activates ENDOTHELIAL
EIF2S1 activates FRONTOTEMPORAL
EIF2S1 activates COPD
EIF2S1 activates SYNUCLEIN
EIF2S1 activates Reactive Oxygen Species
EIF2S1 activates NUCLEUS