gene 1,032 words KG: EMD 2026-03-27
kind:genesection:genesstate:publishedevidence:moderate
Contents

EMD — Emerin

🧬 Gene Info
Gene SymbolEMD
Full NameEmerin
ChromosomeXq28
FunctionThe EMD gene encodes emerin, a 34-kDa integral membrane protein of the inner nuclear envelope.
Primary ExpressionSkeletal Muscle, Cardiac Muscle, Nuclear Envelope
PathwaysMAPK signaling, apoptosis pathway, autophagy pathway, necroptosis, oxidative stress response
UniProt IDP50402
NCBI Gene ID2010
Ensembl IDENSG00000102119
OMIM300384
GeneCardsEMD
Human Protein AtlasEMD
Associated DiseasesAD, ALI, ALS, Alzheimer, Autoimmune
InteractionsMAPK8, RHOT1, BNIP3L, NDP52, HIF1A, MAP1LC3B
KG Connections425 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

APOE-Dependent Autophagy Restoration
Score: 0.61
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Phase-Separated Organelle Targeting
Score: 0.52
Aquaporin-4 Polarization Rescue
Score: 0.51

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

EMD interacts_with MAPK8
EMD interacts_with RHOT1
EMD interacts_with BNIP3L
EMD interacts_with NDP52
EMD interacts_with HIF1A
EMD interacts_with MAP1LC3B
EMD interacts_with GBA
EMD interacts_with FUNDC1
EMD interacts_with AMBRA1
EMD interacts_with PINK1