gene

FER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

5Experiments

0Debates

Summary

FER is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, treats. Associated with ALS, Als, Arthritis. Connected to 131 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FER
Full Name	FER Proto-Oncogene, Tyrosine Kinase
Chromosome	5q31.2
Protein Type	Receptor
Function	The FER gene encodes a non-receptor tyrosine kinase (Fer) that belongs to the FPS/FES family of tyrosine kinases.
Primary Expression	the brain and plays important roles in neuronal signaling, synaptic function, and cell adhesion[@fer2000]
Pathways	Ferroptosis, Oxidative Stress
UniProt ID	[P16591](https://www.uniprot.org/uniprot/P16591)
Ensembl ID	ENSG00000151422
GeneCards	FER
Human Protein Atlas	FER
Postsynaptic density	Fer localizes to PSDs and phosphorylates PSD-95, affecting synaptic scaffolding
Receptor tyrosine kinases	Fer interacts with and regulates signaling from neurotrophin receptors
Synaptic plasticity	Fer activity modulates long-term potentiation (LTP) and long-term depression (LTD)[@yamada2019]
Associated Diseases	Stroke
Interactions	ACSL4, AKT, ALOX12, ALOX15, ALOX5, ALOXE3
KG Connections	208 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    FER["FER"] -->|"activates"| Cancer["Cancer"]
    FER["FER"] -->|"activates"| Als["Als"]
    FER["FER"] -->|"activates"| Arthritis["Arthritis"]
    FER["FER"] -->|"associated with"| Stroke["Stroke"]
    FER["FER"] -->|"activates"| Parkinson["Parkinson"]
    FER["FER"] -->|"biomarker for"| Cardiac["Cardiac"]
    FER["FER"] -->|"therapeutic target"| Ms["Ms"]
    FER["FER"] -->|"biomarker for"| Inflammation["Inflammation"]
    FER["FER"] -->|"activates"| ALS["ALS"]
    FER["FER"] -->|"activates"| Ferroptosis["Ferroptosis"]
    FER["FER"] -.->|"inhibits"| Ferroptosis["Ferroptosis"]
    FER["FER"] -->|"activates"| NFE2L2["NFE2L2"]
    style FER fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Arthritis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ferroptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
Ferroptosis	activates	pathway	0.90
Cancer	activates	disease	0.85
Ferroptosis	inhibits	pathway	0.80
Inflammation	activates	disease	0.75
Tumor	inhibits	disease	0.75
Ferroptosis	treats	pathway	0.70
Autophagy	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Als	biomarker_for	disease	0.65
Fibrosis	activates	disease	0.65
Pulmonary Fibrosis	activates	disease	0.65
Fibrosis	treats	disease	0.65
ALS	regulates	disease	0.65
Als	activates	disease	0.65
Liver Cancer	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Als	inhibits	disease	0.65
Breast Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
Sepsis	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Stroke	associated_with	disease	0.65
Cardiac	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	regulates	disease	0.65
Inflammation	treats	disease	0.65
Arthritis	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
GPX4	expressed_in	gene	0.60
LC3	activates	gene	0.60
GPX4	therapeutic_target	gene	0.60
BAX	activates	gene	0.60
P62	activates	gene	0.60
NRF2	activates	gene	0.60
GPX4	inhibits	gene	0.60
ATG5	activates	gene	0.60
MTOR	activates	gene	0.60
HMGB1	activates	gene	0.60
SLC7A11	regulates	entity	0.60
Ferroptosis	associated_with	pathway	0.60
GPX4	regulates	entity	0.60
HMOX1	activates	gene	0.60
SOX9	activates	gene	0.60
GENES	regulates	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
AKT	activates	gene	0.60

Incoming (98)

Source	Relation	Type	Str
FERROPTOSIS	activates	gene	0.90
CANCER	activates	gene	0.80
FERROPTOSIS	inhibits	gene	0.80
ROS	activates	gene	0.80
GPX4	activates	gene	0.70
P53	activates	gene	0.70
FERROPTOSIS	treats	gene	0.70
TNF-Α	activates	gene	0.70
GPX4	inhibits	gene	0.70
TNF	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
ROS	inhibits	gene	0.70
SLC7A11	activates	gene	0.70
NCOA4	expressed_in	gene	0.60
P62	activates	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
P53	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
PARKINSON	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
RNA	associated_with	gene	0.60
NRF2	activates	gene	0.60
GSH	inhibits	gene	0.60
BECN1	activates	gene	0.60
SIRT3	treats	gene	0.60
NRF2	inhibits	gene	0.60
LC3	activates	gene	0.60
CGAS	activates	gene	0.60
ACSL4	activates	gene	0.60
STAT3	activates	gene	0.60
IL6	activates	gene	0.60
CHAC1	activates	gene	0.60
STAT3	inhibits	gene	0.60
TNF	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
COX2	expressed_in	gene	0.60
ROS	treats	gene	0.60
OXIDATIVE STRESS	treats	gene	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	treats	gene	0.60
FERROPTOSIS	regulates	gene	0.60
ALOXE3	activates	gene	0.60
SAT1	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
STING	activates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.891	alzheimers	Cell type vulnerability in Alzheimers Di
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
HSP90-cochaperone complexes preferentially stabilize interme	0.840	protein-biochemistry	Do chaperones selectively recognize path
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
CREB-Dependent Differential Complement Regulator Positioning	0.833	synaptic-biology	What determines the selectivity of compl

Differential Complement Regulator Expression on Synaptic Mem	0.833	synaptic-biology	What determines the selectivity of compl
Gamma entrainment repairs cross-regional phase-amplitude cou	0.826	alzheimers	Gamma entrainment therapy to restore hip
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt	0.824	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep	0.800	neurodegeneration	Blood-brain barrier antibody transport m
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	alzheimers	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.777	alzheimers	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.776	alzheimers	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.772	alzheimers	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.764	alzheimers	Cell type vulnerability in Alzheimers Di
Iron-driven lipid peroxidation and GPX4 failure create a fer	0.750	neurodegeneration	What mechanisms drive the self-amplifyin
GPX4 reserve failure gates selective ALS motor-neuron ferrop	0.745	neurodegeneration	Ferroptosis in ALS motor neuron vulnerab
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
ACSL4 lipid remodeling creates ferroptosis-prone ALS membran	0.710	neurodegeneration	Ferroptosis in ALS motor neuron vulnerab
Ferroptosis Inhibition for α-Synuclein Neuroprotection	0.705	neurodegeneration	Gene expression changes in aging mouse b
Microglial Efferocytosis Enhancement via GPR32 Superagonists	0.704	neurodegeneration	Neuroinflammation resolution mechanisms
Mitochondrial Transfer Pathway Enhancement	0.695	neurodegeneration	Astrocyte reactivity subtypes in neurode
Endosomal escape determines whether transferred tau becomes	0.694	neurodegeneration	Seed-competent tau conformers in trans-s
Differential Ubiquitin Chain Topology Creates 'Invisible' Su	0.682	neurodegeneration	How do pathological stress granules in n
GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis B	0.680	-	Ferroptosis in ALS and motor neuron dise
Physiological SCFAs may confer indirect anti-synuclein benef	0.670	neurodegeneration	Do physiological concentrations of SCFAs

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice	validation	Alzheimer's disease	0.900	0.00	5xFAD transgenic mice	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	0.00	1-month-old APP/PS1 mice cereb	proposed	N/A
Irisin effects on osteogenic differentiation in mesenchymal stem cells	exploratory	bone fracture	0.900	0.00	mouse bone mesenchymal stem ce	proposed	N/A
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State	in_vivo	neurodegeneration	0.774	0.65	C57BL/6J LPS model (chronic i.	proposed	$58,000
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat	in_vivo	post-cardiac-arrest neurodegen	0.768	0.72	Sprague-Dawley rat asphyxial c	abandoned	$48,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026	0
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085]	Wen H, Zi Y, Liu Z, Bai Y, Lin J et al.	Cell Death Differ	2026	0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026	0
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462]	Tan Y, Ye H, Ge Q, Wang P, Liu Z et al.	J Magn Reson Imaging	2026	0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026	0
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026	0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FER in their description or question text

FER

Understanding Entity Pages

Summary

Wiki Pages (6)

FER Gene

Fermitin-2 (FERMT2 / Kindlin-2)

FERMT2 Gene

FERMT2 Protein

FERMT2 Protein

FERMT2 — Fermitin Family Member 2

Pathway Diagram

Outgoing (110)

Incoming (98)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (5)

Related Papers (20)

Debates (0)

Related Research

Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46)

Gamma entrainment repairs cross-regional phase-amplitude coupling via CA1 Schaff

SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via

SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent N

Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Dise

ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidat

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Diseas

Iron-driven lipid peroxidation and GPX4 failure create a ferroptotic amplificati

GPX4 reserve failure gates selective ALS motor-neuron ferroptosis