Contents

PLG — Plasminogen

🧬 Gene Info

Gene Symbol	PLG
Full Name	Plasminogen
Chromosome	6q26
Function	tPA-mediated activation: Tissue plasminogen activator (tPA) activates plasminogen preferentially in the presence of fibrin, making it important for clot-specific fibrinolysis.
Primary Expression	neurons and can be released in response to neuronal activity
Amino Acids	810 aa
UniProt ID	[P00747](https://www.uniprot.org/uniprot/P00747)
Ensembl ID	ENSG00000122194
GeneCards	PLG
Human Protein Atlas	PLG
PAI-1 (SERPINE1)	Primary inhibitor of tPA and uPA
PAI-2 (SERPINE2)	Alternative inhibitor expressed in brain
Alpha-2 antiplasmin	Direct inhibitor of plasmin
Associated Diseases	Als, Inflammation, Ms
Interactions	NFKB1, TGFB1
KG Connections	38 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph