concept

ACETYL-COA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACETYL-COA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

590Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

ACETYL-COA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 391 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameACETYL-COA
Key Genes/ProteinsSTAT3, AUTOPHAGY, CANCER, MICROGLIA, ATP
Related DiseasesCancer, Tumor, Als, Inflammation, Obesity
Related PathwaysAutophagy

Wiki Pages (20)

Knowledge base pages for this entity

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

mechanism · 4869 words

Autophagy Mechanisms

mechanism · 4866 words

Benfotiamine Phase 2 Alzheimer's Disease Trial (NCT06223360)

clinical · 3941 words

Peroxisome Pathway in Neurodegeneration

mechanism · 3885 words

metabolic-dysfunction-neurodegeneration

mechanism · 3868 words

Pathway Diagram

graph TD
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| STAT3["STAT3"]
    ACETYL_COA -->|"activates"| histone_acetylation["histone acetylation"]
    ACETYL_COA -->|"activates"| Tumor["Tumor"]
    ACETYL_COA -->|"activates"| Ms["Ms"]
    ACETYL_COA -->|"activates"| Als["Als"]
    ACETYL_COA -->|"inhibits"| Cardiovascular["Cardiovascular"]
    ACETYL_COA -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACETYL_COA -->|"interacts"| Alzheimer["Alzheimer"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ACETYL_COA
    AMPK["AMPK"] -->|"activates"| ACETYL_COA
    BNIP3["BNIP3"] -->|"activates"| ACETYL_COA
    BCL2["BCL2"] -->|"activates"| ACETYL_COA
    GLI1["GLI1"] -->|"activates"| ACETYL_COA
    ATG["ATG"] -->|"activates"| ACETYL_COA
    BECN1["BECN1"] -->|"activates"| ACETYL_COA
    ATG7["ATG7"] -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"] -->|"activates"| ACETYL_COA
    MITOPHAGY["MITOPHAGY"] -->|"activates"| ACETYL_COA

Outgoing (367)

TargetRelationTypeStr
Cancerinhibitsdisease0.95
Canceractivatesdisease0.95
STAT3activatesgene0.90
Tumoractivatesdisease0.85
Alsactivatesdisease0.85

Incoming (223)

SourceRelationTypeStr
MITOPHAGYactivatesgene0.70
CANCERinhibitsgene0.70
SIRT1activatesgene0.70
AUTOPHAGYactivatesgene0.60
AMPKactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found