gene 1,969 words KG: STING
Contents

STING Gene

🧬 Gene Info
Gene SymbolSTING
Full NameStimulator of Interferon Genes
AliasesTMEM173
Chromosome5q31.2
Functionis a transmembrane protein that serves as the central signaling hub for the cGAS-STING pathway, one of the most important innate immune sensing mechanisms in eukaryotic cells.
Molecular Weight42 kDa
Amino Acids379 aa
Exons6
PathwaysNF-κB
UniProt IDQ86WV1
NCBI Gene ID340061
Ensembl IDENSG00000184584
OMIM612374
GeneCardsSTING
Human Protein AtlasSTING
Associated DiseasesAD, aging, ALI, Als
Known Drugs/Compounds2'3'-cGAMP, 2'3'-Cgamp, ADUCANUMAB, curcumin, CURCUMIN, dasatinib
InteractionsAB, ACHE, ACSL4, Actin, AD, ADAM10
KG Connections3520 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (196)

Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
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Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (9)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90
TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90
cGAMP biomarker analysis in ALS patient spinal cord samples
clinical · proposed · Score: 0.85
cGAS/STING pathway validation in TDP-43 mutant mice
validation · proposed · Score: 0.85

See Also (7)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: co_discussed
ACTB Gene
gene · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Adaptive Immunity in Neurodegeneration
mechanism · KG edge: causes

Knowledge Graph (12 edges)

CGAS activates STING
STING activates TYPE_I_IFN
P62_SQSTM1 regulates STING
STIM1 inhibits STING
MAX inhibits STING
STING inhibits PARP1
STING activates IRF3
STING activates LC3-associated phagocytosis
PDGFRB activates STING
ANGPT1 activates STING

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