gene 1,654 words KG: VCAM1
Contents

VCAM1 - Vascular Cell Adhesion Molecule 1

🧬 Gene Info
Gene SymbolVCAM1
Full NameVascular Cell Adhesion Molecule 1
AliasesCD106
Chromosome1p21.2
FunctionCell adhesion molecule mediating leukocyte endothelial attachment
Molecular Weight81.3 kDa
Amino Acids739
PathwaysLeukocyte extravasation, NF-kB signaling
UniProt IDP19320
NCBI Gene ID7412
Ensembl IDENSG00000162692
GeneCardsVCAM1
Human Protein AtlasVCAM1
Associated DiseasesAls, Alzheimer, dementia, Inflammation, Multiple Sclerosis
InteractionsAkt, AKT, AMPK, APOPTOSIS, BAX, BCL-2
KG Connections174 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Astrocytes
cell · KG edge: protects_against
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
BACE1 (Redirect)
redirect · KG edge: protects_against
BAX Gene
gene · KG edge: inhibits
CD44 - Cell Surface Glycoprotein
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CXCL10 associated_with VCAM1
TNF associated_with VCAM1
BAX inhibits VCAM1
CXCL2 associated_with VCAM1
PTGS2 associated_with VCAM1
MMP9 associated_with VCAM1
VCAM1 associated_with ICAM1
ICAM1 inhibits VCAM1
VCAM1 inhibits LDLR
VCAM1 inhibits TNF

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