protein 1,299 words KG: IL18 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Interleukin-18 Protein

🔬 Protein Info
Gene SymbolIL18
Full NameInterleukin-18
Chromosome11q22.2-q22.3
FunctionGene expression: The IL18 gene is induced by NF-κB and AP-1 transcription factors in response to TLR ligands, TNF, and IL-1β
Subcellular Localization</b></td><td>Cytoplasm, Secreted</td></tr>
Molecular Weight24 kDa
Amino Acids192 aa
PathwaysNF-κB
UniProt ID[Q14116](https://www.uniprot.org/uniprot/Q14116)
Ensembl IDENSG00000150782
GeneCardsIL18
Human Protein AtlasIL18
Associated DiseasesALS, Alcohol Use Disorder, Alzheimer, Fibrosis, Inflammation, Ms
InteractionsFKBP5, CRH, CRHR1, NR3C1, BDNF, TNF
KG Connections338 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Purinergic Signaling Polarization Control
Score: 0.55
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Microbial Inflammasome Priming Prevention
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

Alzheimer Indonesia
institution · KG edge: activates
ATG7 Gene
gene · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: associated_with
ATG14 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IL18 associated_with UBIQUITIN
IL18 interacts_with IL18BP
IL18 interacts_with RAMP1
IL18 activates NLRP3
IL18 treats IL18BP
IL18 activates JNK
IL18 activates TLR4
IL18 activates IL18BP
IL18 associated_with CASP1
IL18 associated_with ATG5