| Gene Symbol | LC3 |
| Aliases | Microtubule-Associated Protein 1 Light Chain 3 |
| Protein Type | Transcription Factor |
| Function | LC3 is essential for autophagosome formation and function |
| Subcellular Localization | </th><td>Cytoplasm, autophagosome membrane</td></tr> |
| Molecular Weight | 17 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle |
| GeneCards | LC3 |
| Human Protein Atlas | LC3 |
| Pro-LC3 | Full-length protein synthesized in the cytoplasm |
| LC3-I | Cytosolic form after cleavage by ATG4 |
| LC3-II | Lipidated form (conjugated to phosphatidylethanolamine) that associates with autophagosome membranes |
| Autophagosome biogenesis | LC3-II is incorporated into the growing autophagosome membrane |
| Cargo recognition | LC3 binds to autophagy receptors (p62, NDP52, OPTN) that recognize ubiquitinated cargo |
| Selective autophagy | Facilitates selective degradation of damaged organelles, protein aggregates, and intracellular pathogens |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | ATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin |
| Interactions | 6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1 |
| KG Connections | 3247 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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