protein 1,305 words KG: LMNA 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LMNA Protein

🔬 Protein Info
Gene SymbolLMNA
Full NameLMNA
Chromosome1q22
Protein TypeProtein
Function### Nuclear Lamina Structure
Primary ExpressionUniversal (all cell types)
Molecular Weight72 kDa
Amino Acids33 aa
Exons12
Pathwayscalcium_homeostasis
UniProt IDP02545
NCBI Gene ID3999
Ensembl IDENSG00000160789
OMIM150330
GeneCardsLMNA
Human Protein AtlasLMNA
Associated DiseasesAD, ALI, ALS, AMI, Aging
InteractionsAPH1B, APOE, IL6, SREBF1, PSEN2, A2M
KG Connections836 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

LMNA causes DCM
LMNA encodes Lamin_AC
LMNA regulates calcium_homeostasis
LMNA interacts_with APH1B
LMNA interacts_with APOE
LMNA interacts_with IL6
LMNA interacts_with SREBF1
LMNA interacts_with PSEN2
LMNA interacts_with A2M
LMNA interacts_with DHCR24