| Gene Symbol | NRF2 |
| Full Name | Nuclear Factor Erythroid 2-Related Factor 2 |
| Chromosome | 2q31.2 |
| Protein Family | Cap'n'Collar (CNC) bZIP transcription factor |
| Function | Basal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex. |
| Molecular Weight | 68 kDa |
| Amino Acids | 605 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| GeneCards | NRF2 |
| Human Protein Atlas | NRF2 |
| Protein Name [@cuadrado2019]
NRF2 [@pajares2016]
[@dinkovakostova2015]
[@uniprot]
Gene [@allen]
[NFE2L2](/entities/nfe2l2) [@allena]
[@allenb]
[@allenc]
UniProt [@brainspan]
Q16236 [@genes]
[@mechanisms]
[@proteins]
PDB [@hsp]
2FLU, 3WN7 [@psqstm]
[@parkin]
[@pinkprotein]
Molecular Weight [@sodprotein]
~68 kDa (605 amino acids) [@ref]
[@flu]
[@httpswwwncbinlmnihgovgene]
Subcellular Localization | Cytoplasm → Nucleus (upon activation) |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, KAEMPFEROL, Ros, quercetin, 4OI, dimethyl fumarate |
| Interactions | GPX4, CX3CR1, TNF, CD163, CD68, ULK1 |
| KG Connections | 3350 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |