protein 1,258 words KG: SPR 2026-03-29
kind:proteinsection:proteinstopic:parkinsonsstate:published
Contents

Sepiapterin Reductase (SPR)

🔬 Protein Info
Gene SymbolSPR
Protein TypeEnzyme
FunctionGTP cyclohydrolase I (GCH1): GTP → 7,8-dihydroneopterin triphosphate
Subcellular LocalizationCytosolic
PathwaysImmune Response
Ensembl IDENSG00000166347
GeneCardsSPR
Human Protein AtlasSPR
Associated DiseasesALS, Ischemia, Ms
InteractionsHK2, TNF, NLRP3, LRP1, PARKIN, FER
KG Connections251 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.51
Aquaporin-4 Polarization Rescue
Score: 0.51
Microglial Purinergic Reprogramming
Score: 0.48
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Sphingolipid Metabolism Reprogramming
Score: 0.44

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · failed

Related Experiments (6)

Molecular characterization of RBG-NLRP3 binding interaction
exploratory · proposed · Score: 0.90
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: therapeutic_target
BAX Gene
gene · KG edge: associated_with
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

SPR inhibits HK2
SPR associated_with PPARGC1A
SPR associated_with CASP3
SPR associated_with PDK1
SPR associated_with PDK4
SPR associated_with SOD1
SPR associated_with TNFR2
SPR associated_with BCL2
SPR associated_with SLC16A1
SPR inhibits TNF