| Gene Symbol | SPR |
| Protein Type | Enzyme |
| Function | GTP cyclohydrolase I (GCH1): GTP → 7,8-dihydroneopterin triphosphate |
| Subcellular Localization | Cytosolic |
| Pathways | Immune Response |
| Ensembl ID | ENSG00000166347 |
| GeneCards | SPR |
| Human Protein Atlas | SPR |
| 1QPD | Saccharomyces cerevisiae SPR complexed with NADPH (2.0 Å resolution) — reveals cofactor binding mode |
| 1ZTR | Human SPR in complex with cofactor and inhibitor analogs (1.8 Å) — guides drug design |
| 2NBQ | Mutant SPR variants from SRD patients — structure-function relationships |
| AlphaFold2 | Predicted full-length human SPR structure consistent with biochemical data |
| Associated Diseases | ALS, Ischemia, Ms |
| Interactions | AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, App, APP |
| KG Connections | 245 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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