protein

ALKBH5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALKBH5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

Summary

Page for ALKBH5 Protein (AlkB Homolog 5)

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🔬 Protein Info

Gene Symbol	ALKBH5
Aliases	AlkB Homolog 5
Function	ALKBH5 (AlkB Homolog 5) is a 259-amino acid nuclear protein that functions as an N6-methyladenosine (m6A) demethylase.
Subcellular Localization	</strong> Nucleus</div> <div class="infobox-row"><strong>Protein Family:</stro
Molecular Weight	29.4 kDa
Amino Acids	259 aa
Pathways	Spermatogenesis
GeneCards	ALKBH5
Human Protein Atlas	ALKBH5
Associated Diseases	Fertility, Male Infertility, Parkinson, Parkinson'S Disease, neurodegeneration
Known Drugs/Compounds	N6-Methyladenosine
Interactions	RNA, AND, JUN, APOPTOSIS, P53, TP53
KG Connections	73 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (15)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALKBH5(["ALKBH5"])
    MRNA["MRNA"]
    N_6__methyladenosine["N(6)-methyladenosine"]
    N6_Methyladenosine["N6-Methyladenosine"]
    RNA_Methylation["RNA Methylation"]
    astrocytes["astrocytes"]
    MRNA_EXPORT["MRNA EXPORT"]
    mRNA_Metabolism["mRNA Metabolism"]
    Fertility["Fertility"]
    m6A_Modification["m6A Modification"]
    mRNA_Export["mRNA Export"]
    Male_Fertility["Male Fertility"]
    SLC1A2["SLC1A2"]
    depression_related_behaviors["depression-related behaviors"]
    environmental_stress["environmental stress"]
    APOPTOSIS["APOPTOSIS"]
    TP53["TP53"]
    Spermatogenesis["Spermatogenesis"]
    major_depressive_disorder["major depressive disorder"]
    Cancer["Cancer"]
    ALS["ALS"]
    ALKBH5 -->|"regulates"| MRNA
    ALKBH5 -->|"catalyzes"| N_6__methyladenosine
    ALKBH5 -->|"catalyzes"| N6_Methyladenosine
    ALKBH5 -->|"regulates"| RNA_Methylation
    ALKBH5 -->|"expressed in"| astrocytes
    ALKBH5 -->|"modulates"| MRNA_EXPORT
    ALKBH5 -->|"regulates"| mRNA_Metabolism
    ALKBH5 -.-|"associated"| Fertility
    ALKBH5 -->|"modulates"| m6A_Modification
    ALKBH5 -->|"modulates"| mRNA_Export
    ALKBH5 -.-|"associated"| Male_Fertility
    ALKBH5 -->|"regulates"| SLC1A2
    ALKBH5 -->|"modulates"| depression_related_behaviors
    environmental_stress -->|"activates"| ALKBH5
    ALKBH5 -->|"regulates"| APOPTOSIS
    ALKBH5 -.-|"associated"| TP53
    ALKBH5 -->|"involved in"| Spermatogenesis
    ALKBH5 -->|"biomarker_for"| major_depressive_disorder
    ALKBH5 -->|"contributes_to"| Cancer
    ALKBH5 -->|"contributes_to"| ALS
    style ALKBH5 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (59)

Target	Relation	Type	Str
MRNA	regulates	entity	0.95
astrocytes	expressed_in	cell_type	0.95
N6-Methyladenosine	modulates	compound	0.95
Male Infertility	associated_with	phenotype	0.95
MRNA EXPORT	modulates	entity	0.90
mRNA Metabolism	regulates	process	0.90
Fertility	associated_with	phenotype	0.90
SLC1A2	regulates	gene	0.90
depression-related behaviors	modulates	phenotype	0.90
Mrna Export	regulates	process	0.90
Rna Metabolism	regulates	process	0.90
m6A modification	inhibits	process	0.90
male fertility	regulates	phenotype	0.90
m6A	demethylates	modification	0.90
APOPTOSIS	regulates	entity	0.88
TP53	associated_with	entity	0.85
major depressive disorder	biomarker_for	disease	0.85
Mrna Processing	regulates	process	0.85
m6A methylation	regulates	process	0.85
Parkinson'S Disease	implicated_in	disease	0.85
RNA metabolism	impacts	process	0.80
Mouse fertility	impacts	process	0.80
TP53	regulates	gene	0.75
TP53	interacts_with	gene	0.70
Cancer	contributes_to	disease	0.65
ALS	contributes_to	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
RNA	activates	gene	0.60
AND	activates	gene	0.60
JUN	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
P53	activates	gene	0.60
Apoptosis	activates	pathway	0.60
AND	associated_with	gene	0.60
FTO	associated_with	gene	0.60
YTHDF1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
IGF2BP1	contributes_to	gene	0.60
METTL3	associated_with	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
Igf	therapeutic_target	protein	0.60
Ras	associated_with	protein	0.60
Rb	associated_with	protein	0.60
RNA	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
METTL3	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60

Incoming (19)

Source	Relation	Type	Str
environmental stress	activates	process	0.90
spermatogenesis	associated_with	process	0.85
GENES	activates	gene	0.60
GENES	contributes_to	gene	0.60
HNRNPA2B1	contributes_to	gene	0.60
WTAP	associated_with	gene	0.60
RNA	contributes_to	gene	0.60
APOPTOSIS	activates	gene	0.60
RNA	activates	gene	0.60
JUN	activates	gene	0.60
P53	activates	gene	0.60
FTO	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
IGF2BP1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
METTL3	associated_with	gene	0.60
AND	associated_with	gene	0.60
YTHDF1	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ALKBH5

Understanding Entity Pages

Summary

Wiki Pages (15)

Epigenetic Mechanisms in Alzheimer's Disease

Epigenetic Alterations in Alzheimer's Disease

RNA Stability and Decay

Transcriptional Dysregulation in Neurodegeneration

RNA Metabolism Dysfunction in Corticobasal Syndrome

VIRMA (KIAA1429) in Neurodegeneration

Section 183: Epitranscriptomics and RNA Modifications in CBS/PSP

payload-ythdf-m6a-reader-modulation-therapy

Epitranscriptomics and RNA Modifications in CBS/PSP

VIRMA (KIAA1429)

m6A RNA Methylation Modulation Therapy for Neurodegeneration

m6A RNA Methylation (Epitranscriptomics) in Neurodegeneration

ALKBH5 Protein (AlkB Homolog 5)