gene

RBFOX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RBFOX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections
0Hypotheses
0Analyses
9Outgoing
48Incoming

Summary

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

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🧬 Gene Info
Gene SymbolRBFOX3
Full NameRNA Binding Fox-3 Homolog (NeuN) (RBFOX3)
AliasesRNA Binding Protein Fox-3
Chromosome17q21.31
Protein TypeGene
FunctionNuclear Localization: Predominantly localizes to the nucleus of most post-mitotic neurons.
Primary Expressionnearly all neurons in the central and peripheral nervous system
UniProt IDQ8WWI5
NCBI Gene ID22998
Ensembl IDENSG00000161981
GeneCardsRBFOX3
Human Protein AtlasRBFOX3
Associated DiseasesRett Syndrome, Intellectual Disability, Epilepsy, Autism Spectrum Disorder
Known Drugs/Compoundsrapamycin
InteractionsWDR45, RNA, AIF1, ARC, CAMKK2, COX4I1
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RBFOX3 — AlphaFold Q8WWI5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

gene · 1010 words

CBS Epigenetic Mechanisms

mechanism · 1864 words

pontine-nucleus-neurons

cell_type · 1773 words

POU3F2 — POU Class 3 Homeobox 2

gene · 1755 words

Hippocampal CA3 Neurons

cell · 1737 words

Nucleus Gracilis Neurons

cell · 1677 words

Pathway Diagram

flowchart TD
    N0["RBFOX3"]
    N1["AIF1"]
    N1 -->|"activates"| N0
    N2["AMPK"]
    N2 -->|"activates"| N0
    N3["ARC"]
    N3 -->|"activates"| N0
    N4["CAMKK2"]
    N4 -->|"activates"| N0
    N5["COX4I1"]
    N5 -->|"activates"| N0
    N6["GFAP"]
    N6 -->|"activates"| N0
    N7["IBA1"]
    N7 -->|"activates"| N0
    N8["LAMP2"]
    N8 -->|"activates"| N0
    N9["RNA"]
    N0 -->|"activates"| N9
    N10["autophagy pathway"]
    N0 -->|"participates in"| N10
    N11["ubiquitin-proteasome"]
    N0 -->|"participates in"| N11
    N12["Alzheimer's disease"]
    N0 -->|"activates"| N12
    N13["neurodegeneration"]
    N0 -->|"activates"| N13
    N14["WDR45"]
    N0 -->|"activates"| N14
    N15["traumatic brain injury"]
    N0 -->|"activates"| N15
    N16["autism spectrum disorder"]
    N0 -->|"activates"| N16

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    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 pathway
    class N11 pathway
    class N12 disease
    class N13 disease
    class N14 gene
    class N15 disease
    class N16 disease

Outgoing (9)

TargetRelationTypeStr
RNAactivatesgene0.80
neurodegenerationactivatesdisease0.60
WDR45activatesgene0.60
autophagy pathwayparticipates_inpathway0.60
ubiquitin-proteasomeparticipates_inpathway0.60

Incoming (48)

SourceRelationTypeStr
AIF1activatesgene0.60
ARCactivatesgene0.60
CAMKK2activatesgene0.60
COX4I1activatesgene0.60
GFAPactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found