Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RBFOX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RBFOX3 |
| Full Name | RNA Binding Fox-3 Homolog (NeuN) (RBFOX3) |
| Aliases | RNA Binding Protein Fox-3 |
| Chromosome | 17q21.31 |
| Protein Type | Gene |
| Function | Nuclear Localization: Predominantly localizes to the nucleus of most post-mitotic neurons. |
| Primary Expression | nearly all neurons in the central and peripheral nervous system |
| UniProt ID | Q8WWI5 |
| NCBI Gene ID | 22998 |
| Ensembl ID | ENSG00000161981 |
| GeneCards | RBFOX3 |
| Human Protein Atlas | RBFOX3 |
| Associated Diseases | Rett Syndrome, Intellectual Disability, Epilepsy, Autism Spectrum Disorder |
| Known Drugs/Compounds | rapamycin |
| Interactions | WDR45, RNA, AIF1, ARC, CAMKK2, COX4I1 |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["RBFOX3"]
N1["AIF1"]
N1 -->|"activates"| N0
N2["AMPK"]
N2 -->|"activates"| N0
N3["ARC"]
N3 -->|"activates"| N0
N4["CAMKK2"]
N4 -->|"activates"| N0
N5["COX4I1"]
N5 -->|"activates"| N0
N6["GFAP"]
N6 -->|"activates"| N0
N7["IBA1"]
N7 -->|"activates"| N0
N8["LAMP2"]
N8 -->|"activates"| N0
N9["RNA"]
N0 -->|"activates"| N9
N10["autophagy pathway"]
N0 -->|"participates in"| N10
N11["ubiquitin-proteasome"]
N0 -->|"participates in"| N11
N12["Alzheimer's disease"]
N0 -->|"activates"| N12
N13["neurodegeneration"]
N0 -->|"activates"| N13
N14["WDR45"]
N0 -->|"activates"| N14
N15["traumatic brain injury"]
N0 -->|"activates"| N15
N16["autism spectrum disorder"]
N0 -->|"activates"| N16
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classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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class N0 gene
class N1 gene
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene
class N10 pathway
class N11 pathway
class N12 disease
class N13 disease
class N14 gene
class N15 disease
class N16 disease| Target | Relation | Type | Str |
|---|---|---|---|
| RNA | activates | gene | 0.80 |
| neurodegeneration | activates | disease | 0.60 |
| WDR45 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| Alzheimer's disease | activates | disease | 0.60 |
| traumatic brain injury | activates | disease | 0.60 |
| autism spectrum disorder | activates | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AIF1 | activates | gene | 0.60 |
| ARC | activates | gene | 0.60 |
| CAMKK2 | activates | gene | 0.60 |
| COX4I1 | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| IBA1 | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| NEFM | activates | gene | 0.60 |
| NFM | activates | gene | 0.60 |
| NPY | activates | gene | 0.60 |
| POMC | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| ATG12 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| ATG7 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| CTSL | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| NAGLU | activates | gene | 0.60 |
| PLA2G4A | activates | gene | 0.60 |
| ATF6 | activates | gene | 0.60 |
| CHOP | activates | gene | 0.60 |
| DDIT3 | activates | gene | 0.60 |
| EIF2A | activates | gene | 0.60 |
| EIF2AK3 | activates | gene | 0.60 |
| ERN1 | activates | gene | 0.60 |
| HSP70 | activates | gene | 0.60 |
| HSPA5 | activates | gene | 0.60 |
| IRE1 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| PERK | activates | gene | 0.60 |
| CNP | associated_with | gene | 0.60 |
| NEFL | associated_with | gene | 0.60 |
| NPTX1 | associated_with | gene | 0.60 |
| CCL25 | associated_with | gene | 0.60 |
| MMP1 | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| DNA | activates | gene | 0.60 |
| FTLD | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||