gene

CTSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections
0Hypotheses
0Analyses
27Outgoing
19Incoming

Summary

Page for CTSF Gene (CLN10)

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🧬 Gene Info
Gene SymbolCTSF
Full NameCathepsin F
AliasesCLN10
Chromosome11q13.2
Protein TypeProtease
FunctionThe protein is synthesized as a preproenzyme and processed to its active form within lysosomes.
Primary ExpressionCerebral cortex, Cerebellum, Lysosomal tissues
Molecular Weight52 kDa
Amino Acids462 aa
PathwaysIMMUNE RESPONSE
UniProt IDQ9UJW0
NCBI Gene ID8722
Ensembl IDENSG00000174080
OMIM608536
GeneCardsCTSF
Human Protein AtlasCTSF
Associated DiseasesALS, Alzheimer
KG Connections46 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CTSF — AlphaFold Q9UJW0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

CTSF Gene (CLN10)

gene · 971 words

Neuronal Ceroid Lipofuscinosis (NCL)

disease · 4122 words

CTSF Protein (Cathepsin F)

protein · 1098 words

GRN Carrier Resilience in Frontotemporal Dementia

gap · 1066 words

MFSD8 — Major Facilitator Superfamily Domain Containing 8

gene · 857 words

C5 Protein

protein · 682 words

Pathway Diagram

graph TD
    CTSF["<b>CTSF</b>"]
    Alzheimer["Alzheimer"]
    CTSF -->|"associated with"| Alzheimer
    Als["Als"]
    CTSF -->|"associated with"| Als
    ALS["ALS"]
    CTSF -->|"associated with"| ALS
    VEGFB["VEGFB"]
    CTSF -->|"associated with"| VEGFB
    APOE["APOE"]
    CTSF -->|"associated with"| APOE
    BIN1["BIN1"]
    CTSF -->|"associated with"| BIN1
    SMPD1["SMPD1"]
    CTSF -->|"associated with"| SMPD1
    CFB["CFB"]
    CTSF -->|"associated with"| CFB
    Immune_Response["Immune Response"]
    CTSF -->|"associated with"| Immune_Response
    Endothelial["Endothelial"]
    CTSF -->|"associated with"| Endothelial
    AND["AND"]
    CTSF -->|"associated with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CTSF -->|"associated with"| ALZHEIMER_S_DISEASE
    Myelination["Myelination"]
    CTSF -->|"associated with"| Myelination
    ACHE["ACHE"]
    ACHE -->|"associated with"| CTSF
    VEGFA["VEGFA"]
    VEGFA -->|"associated with"| CTSF
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| CTSF
    CLU["CLU"]
    CLU -->|"associated with"| CTSF
    CFB["CFB"]
    CFB -->|"associated with"| CTSF
    SMPD1["SMPD1"]
    SMPD1 -->|"associated with"| CTSF
    APOE["APOE"]
    APOE -->|"associated with"| CTSF
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_DISEASE -->|"associated with"| CTSF
    SMOC2["SMOC2"]
    SMOC2 -->|"associated with"| CTSF
    BIN1["BIN1"]
    BIN1 -->|"associated with"| CTSF
    neurodegeneration["neurodegeneration"]
    CTSF -->|"implicated in"| neurodegeneration

Outgoing (27)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
ALSassociated_withdisease0.65
VEGFBassociated_withgene0.60
APOEassociated_withgene0.60

Incoming (19)

SourceRelationTypeStr
VEGFAassociated_withgene0.60
CLUassociated_withgene0.60
CFBassociated_withgene0.60
SMPD1associated_withgene0.60
APOEassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found