Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CTSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CTSF |
| Full Name | Cathepsin F |
| Aliases | CLN10 |
| Chromosome | 11q13.2 |
| Protein Type | Protease |
| Function | The protein is synthesized as a preproenzyme and processed to its active form within lysosomes. |
| Primary Expression | Cerebral cortex, Cerebellum, Lysosomal tissues |
| Molecular Weight | 52 kDa |
| Amino Acids | 462 aa |
| Pathways | IMMUNE RESPONSE |
| UniProt ID | Q9UJW0 |
| NCBI Gene ID | 8722 |
| Ensembl ID | ENSG00000174080 |
| OMIM | 608536 |
| GeneCards | CTSF |
| Human Protein Atlas | CTSF |
| Associated Diseases | ALS, Alzheimer |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CTSF["<b>CTSF</b>"]
Alzheimer["Alzheimer"]
CTSF -->|"associated with"| Alzheimer
Als["Als"]
CTSF -->|"associated with"| Als
ALS["ALS"]
CTSF -->|"associated with"| ALS
VEGFB["VEGFB"]
CTSF -->|"associated with"| VEGFB
APOE["APOE"]
CTSF -->|"associated with"| APOE
BIN1["BIN1"]
CTSF -->|"associated with"| BIN1
SMPD1["SMPD1"]
CTSF -->|"associated with"| SMPD1
CFB["CFB"]
CTSF -->|"associated with"| CFB
Immune_Response["Immune Response"]
CTSF -->|"associated with"| Immune_Response
Endothelial["Endothelial"]
CTSF -->|"associated with"| Endothelial
AND["AND"]
CTSF -->|"associated with"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
CTSF -->|"associated with"| ALZHEIMER_S_DISEASE
Myelination["Myelination"]
CTSF -->|"associated with"| Myelination
ACHE["ACHE"]
ACHE -->|"associated with"| CTSF
VEGFA["VEGFA"]
VEGFA -->|"associated with"| CTSF
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated with"| CTSF
CLU["CLU"]
CLU -->|"associated with"| CTSF
CFB["CFB"]
CFB -->|"associated with"| CTSF
SMPD1["SMPD1"]
SMPD1 -->|"associated with"| CTSF
APOE["APOE"]
APOE -->|"associated with"| CTSF
ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
ALZHEIMER_DISEASE -->|"associated with"| CTSF
SMOC2["SMOC2"]
SMOC2 -->|"associated with"| CTSF
BIN1["BIN1"]
BIN1 -->|"associated with"| CTSF
neurodegeneration["neurodegeneration"]
CTSF -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| VEGFB | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| CFB | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| Vegf | associated_with | protein | 0.60 |
| SMPD1 | causes | gene | 0.60 |
| DNAJC7 | implicated_in | gene | 0.60 |
| GLT8D1 | implicated_in | gene | 0.60 |
| KIF5A | implicated_in | gene | 0.60 |
| MFSD8 | implicated_in | gene | 0.60 |
| NEK1 | implicated_in | gene | 0.60 |
| TBK1 | implicated_in | gene | 0.60 |
| TBP | implicated_in | gene | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| Endothelial | associated_with | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| Myelination | associated_with | pathway | 0.60 |
| BIN1 | regulates | gene | 0.50 |
| IMMUNE RESPONSE | regulates | pathway | 0.50 |
| disease | regulates | disease | 0.50 |
| Proteins | regulates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| VEGFA | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CFB | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| VEGFB | associated_with | gene | 0.60 |
| APOE | causes | gene | 0.60 |
| BIN1 | causes | gene | 0.60 |
| C5 | causes | gene | 0.60 |
| CFB | causes | gene | 0.60 |
| CLU | causes | gene | 0.60 |
| CCNF | implicated_in | gene | 0.60 |
| ACHE | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ALZHEIMER DISEASE | associated_with | gene | 0.60 |
| SMOC2 | associated_with | gene | 0.60 |
| APOE | regulates | gene | 0.50 |
| SMPD1 | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||