gene

CFB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

95Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

CFB — Complement Factor B

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🧬 Gene Info

Gene Symbol	CFB
Full Name	Complement Factor B
Protein Type	Protease
Function	Complement Factor B (CFB) is a serine protease that plays a critical role in the alternative pathway of the complement system.
Pathways	Alternative Complement Pathway, Glycolysis, Complement, Immune Response, Myelination
GeneCards	CFB
Human Protein Atlas	CFB
Multiple Sclerosis	CFB expression is elevated in demyelinating lesions [9]
Brain	CFB is expressed at low levels in healthy brain tissue, primarily by astrocytes and microglia
Regional Distribution	Higher expression in the hippocampus and cerebral cortex
Upregulation	Strongly induced during neuroinflammation and in neurodegenerative disease states
Cellular Localization	Secreted protein, localizes to blood-brain barrier and choroid plexus in brain
Associated Diseases	ALS, Alzheimer
Interactions	Hemoglobin, RIPK1, TNF, IL-6, NEURODEGENERATION, NEUROINFLAMMATION
KG Connections	95 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CFB["CFB"]
    Alternative_Complement_Pathway["Alternative Complement Pathway"]
    Hypertension["Hypertension"]
    Autoimmune["Autoimmune"]
    Neurodegeneration["Neurodegeneration"]
    Neuroinflammation["Neuroinflammation"]
    Inflammation["Inflammation"]
    Glaucoma["Glaucoma"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    IL_6["IL-6"]
    Glycolysis["Glycolysis"]
    Complement["Complement"]
    Immune_Response["Immune Response"]
    GLAUCOMA["GLAUCOMA"]
    NEURODEGENERATION["NEURODEGENERATION"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    COMPLEMENT["COMPLEMENT"]
    AND["AND"]
    CYTOKINES["CYTOKINES"]
    CFB -->|"component_of"| Alternative_Complement_Pathway
    CFB -->|"activates"| Hypertension
    CFB -->|"activates"| Autoimmune
    CFB -->|"activates"| Neurodegeneration
    CFB -->|"activates"| Neuroinflammation
    CFB -->|"activates"| Inflammation
    CFB -->|"activates"| Glaucoma
    CFB -.->|"inhibits"| Neuroinflammation
    CFB -.-|"associated"| Alzheimer
    CFB -.-|"associated"| Als
    CFB -->|"activates"| IL_6
    CFB -->|"activates"| Glycolysis
    CFB -->|"activates"| Complement
    CFB -->|"activates"| Immune_Response
    CFB -->|"activates"| GLAUCOMA
    CFB -->|"activates"| NEURODEGENERATION
    CFB -->|"activates"| NEUROINFLAMMATION
    CFB -->|"activates"| COMPLEMENT
    CFB -->|"activates"| AND
    CFB -.->|"inhibits"| CYTOKINES
    style CFB fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (68)

Target	Relation	Type	Str
Alternative Complement Pathway	component_of	pathway	0.95
Hypertension	activates	disease	0.65
Autoimmune	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Glaucoma	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	associated_with	disease	0.65
STAT1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
JNK	expressed_in	gene	0.60
SMPD1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CLU	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
CTSF	associated_with	gene	0.60
VEGFB	associated_with	gene	0.60
Hemoglobin	inhibits	protein	0.60
Vegf	associated_with	protein	0.60
JNK	biomarker_for	gene	0.60
STAT1	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
CLU	causes	gene	0.60
CTSF	causes	gene	0.60
SMPD1	causes	gene	0.60
CR1	expressed_in	gene	0.60
RIPK1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
IL-6	activates	gene	0.60
Glycolysis	activates	pathway	0.60
Complement	activates	pathway	0.60
Immune Response	activates	pathway	0.60
GLAUCOMA	activates	entity	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
AND	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	expressed_in	cell_type	0.60
Immune Response	associated_with	pathway	0.60
Endothelial	associated_with	cell_type	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AND	expressed_in	gene	0.60

Incoming (27)

Source	Relation	Type	Str
STAT1	expressed_in	gene	0.60
VEGFA	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CTSF	associated_with	gene	0.60
VEGFB	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
C3	biomarker_for	gene	0.60
APOE	causes	gene	0.60
BIN1	causes	gene	0.60
C5	causes	gene	0.60
C5	expressed_in	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ACHE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
SMOC2	associated_with	gene	0.60
CCL2	inhibits	gene	0.60
C1R	expressed_in	gene	0.55
C1S	expressed_in	gene	0.55
C3	expressed_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CFB

Understanding Entity Pages

Summary

Wiki Pages (13)

CFB — Complement Factor B

Complement Activation in Corticobasal Degeneration

Complement Dysregulation in CBS and 4R Tauopathies

C1S Gene

C2 (Complement Component 2)

Retinal Cone Photoreceptors

CTSF Gene (CLN10)

CFH

C5 Protein

CFB Protein — Complement Factor B

C5