protein

C5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections
0Hypotheses
4Analyses
25Outgoing
9Incoming

Summary

Page for C5 Protein

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🔬 Protein Info
Gene SymbolC5
Protein FamilyComplement system
FunctionThe C5 gene encodes a component of the complement system, part of the innate immune system involved in inflammation and immune response.
Subcellular LocalizationPlasma
Molecular Weight190 kDa
PathwaysMembrane Attack Complex
UniProt IDP01031
GeneCardsC5
Human Protein AtlasC5
C5aA potent anaphylatoxin and pro-inflammatory mediator
C5bThe initiating fragment for formation of the membrane attack complex (MAC)
Huntington's DiseaseElevated C5a levels have been observed in HD models and may contribute to disease progression.
Associated Diseasesneurodegeneration
InteractionsCD19, CR1, AQP4, C3
KG Connections34 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: C5 — AlphaFold P01031 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

C5

gene · 534 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

Parthanatos in Neurodegeneration

mechanism · 6619 words

Therapeutics

index · 5665 words

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

mechanism · 5083 words

Pathway Diagram

flowchart TD
    N0["C5"]
    N1["Membrane Attack Complex Stress"]
    N0 -->|"mediates"| N1
    N2["Membrane Attack Complex"]
    N0 -->|"involved in"| N2
    N0 -->|"involved in"| N1
    N3["Glaucoma"]
    N0 -->|"involved in"| N3
    N0 -->|"upregulates"| N3
    N4["CR1"]
    N0 -->|"co discussed"| N4
    N5["C3"]
    N5 -->|"co discussed"| N0
    N6["C1Q"]
    N6 -->|"co discussed"| N0
    N7["neurodegeneration"]
    N0 -->|"implicated in"| N7

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 mechanism
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene

Outgoing (25)

TargetRelationTypeStr
Membrane Attack Complex Stresspromotesmechanism0.88
Membrane Attack Complex Stressmediatesprocess0.85
Membrane Attack Complexinvolved_inmechanism0.85
Membrane Attack Complex Stressinvolved_inprocess0.85
Membrane Attack Complex Formationactivatesprocess0.85

Incoming (9)

SourceRelationTypeStr
AQP4inhibitsgene0.60
C3activatesgene0.60
C3inhibitsgene0.60
APOEcausesgene0.60
BIN1causesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

How can circuit-level neurodegeneration mechanisms be identified without complet

research methodology | 2026-04-11 | 0 hypotheses

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found