gene

DLC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections
0Hypotheses
0Analyses
12Outgoing
13Incoming

Summary

DLC1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, implicated in. Associated with Cancer, Carcinoma, Ms. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDLC1
AliasesPage for DLC1 Gene
Chromosome8p22.
FunctionDLC1 (Deleted in Liver Cancer 1) is a GTPase-activating protein (GAP) that specifically inactivates Rho family GTPases, primarily RhoA, Rac1, and Cdc42.
Primary Expressiondopaminergic neurons where it may protect against oxidative stress
PathwaysApoptosis, Wnt, Mapk
Ensembl IDENSG00000121667
GeneCardsDLC1
Human Protein AtlasDLC1
Associated Diseasesneurodegeneration
InteractionsKCNH1, NCAM1, RGS1, RAB27A, TLR4, TNC
KG Connections25 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

DLC1 Gene - Deleted in Liver Cancer 1

gene · 649 words

PEN2 Gene

gene · 4033 words

DCC

gene · 2541 words

LFNG Gene - Lunatic Fringe

gene · 600 words

NOTCH4 Gene - Notch Receptor 4

gene · 592 words

Genes

index · 271 words

Pathway Diagram

graph TD
    DLC1["<b>DLC1</b>"]
    Carcinoma{"Carcinoma"}
    DLC1 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    DLC1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    DLC1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    DLC1 -->|"inhibits"| Tumor
    KCNH1["KCNH1"]
    DLC1 -->|"inhibits"| KCNH1
    NCAM1["NCAM1"]
    DLC1 -->|"inhibits"| NCAM1
    RGS1["RGS1"]
    DLC1 -->|"inhibits"| RGS1
    RAB27A["RAB27A"]
    DLC1 -->|"inhibits"| RAB27A
    COL4A1["COL4A1"]
    DLC1 -->|"associated with"| COL4A1
    Apoptosis(["Apoptosis"])
    DLC1 -->|"inhibits"| Apoptosis
    Wnt(["Wnt"])
    DLC1 -->|"associated with"| Wnt
    Mapk(["Mapk"])
    DLC1 -->|"inhibits"| Mapk
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| DLC1
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| DLC1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| DLC1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| DLC1
    TNC["TNC"]
    TNC -->|"inhibits"| DLC1
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| DLC1
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| DLC1
    WNT7A["WNT7A"]
    WNT7A -->|"associated with"| DLC1
    LZTS1["LZTS1"]
    LZTS1 -->|"associated with"| DLC1
    DCC["DCC"]
    DCC -->|"associated with"| DLC1
    KCNK2["KCNK2"]
    KCNK2 -->|"inhibits"| DLC1
    CD44["CD44"]
    CD44 -->|"inhibits"| DLC1
    style DLC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
Carcinomainhibitsdisease0.65
Msinhibitsdisease0.65
Cancerinhibitsdisease0.65
Tumorinhibitsdisease0.65
KCNH1inhibitsgene0.60

Incoming (13)

SourceRelationTypeStr
CDKN2Aassociated_withgene0.60
TLR4inhibitsgene0.60
TNCinhibitsgene0.60
NTRK2inhibitsgene0.60
PAK1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found