Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLC1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, implicated in. Associated with Cancer, Carcinoma, Ms. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | DLC1 |
| Aliases | Page for DLC1 Gene |
| Chromosome | 8p22. |
| Function | DLC1 (Deleted in Liver Cancer 1) is a GTPase-activating protein (GAP) that specifically inactivates Rho family GTPases, primarily RhoA, Rac1, and Cdc42. |
| Primary Expression | dopaminergic neurons where it may protect against oxidative stress |
| Pathways | Apoptosis, Wnt, Mapk |
| Ensembl ID | ENSG00000121667 |
| GeneCards | DLC1 |
| Human Protein Atlas | DLC1 |
| Associated Diseases | neurodegeneration |
| Interactions | KCNH1, NCAM1, RGS1, RAB27A, TLR4, TNC |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DLC1["<b>DLC1</b>"]
Carcinoma{"Carcinoma"}
DLC1 -->|"inhibits"| Carcinoma
Ms{"Ms"}
DLC1 -->|"inhibits"| Ms
Cancer{"Cancer"}
DLC1 -->|"inhibits"| Cancer
Tumor{"Tumor"}
DLC1 -->|"inhibits"| Tumor
KCNH1["KCNH1"]
DLC1 -->|"inhibits"| KCNH1
NCAM1["NCAM1"]
DLC1 -->|"inhibits"| NCAM1
RGS1["RGS1"]
DLC1 -->|"inhibits"| RGS1
RAB27A["RAB27A"]
DLC1 -->|"inhibits"| RAB27A
COL4A1["COL4A1"]
DLC1 -->|"associated with"| COL4A1
Apoptosis(["Apoptosis"])
DLC1 -->|"inhibits"| Apoptosis
Wnt(["Wnt"])
DLC1 -->|"associated with"| Wnt
Mapk(["Mapk"])
DLC1 -->|"inhibits"| Mapk
CDKN2A["CDKN2A"]
CDKN2A -->|"associated with"| DLC1
TLR4["TLR4"]
TLR4 -->|"inhibits"| DLC1
CANCER["CANCER"]
CANCER -->|"inhibits"| DLC1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| DLC1
TNC["TNC"]
TNC -->|"inhibits"| DLC1
NTRK2["NTRK2"]
NTRK2 -->|"inhibits"| DLC1
PAK1["PAK1"]
PAK1 -->|"inhibits"| DLC1
WNT7A["WNT7A"]
WNT7A -->|"associated with"| DLC1
LZTS1["LZTS1"]
LZTS1 -->|"associated with"| DLC1
DCC["DCC"]
DCC -->|"associated with"| DLC1
KCNK2["KCNK2"]
KCNK2 -->|"inhibits"| DLC1
CD44["CD44"]
CD44 -->|"inhibits"| DLC1
style DLC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| KCNH1 | inhibits | gene | 0.60 |
| NCAM1 | inhibits | gene | 0.60 |
| RGS1 | inhibits | gene | 0.60 |
| RAB27A | inhibits | gene | 0.60 |
| COL4A1 | associated_with | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CDKN2A | associated_with | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | associated_with | gene | 0.60 |
| LZTS1 | associated_with | gene | 0.60 |
| DCC | associated_with | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||