gene

RGS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections
0Hypotheses
0Analyses
19Outgoing
30Incoming

Summary

Page for RGS1 — Regulator of G Protein Signaling 1

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🧬 Gene Info
Gene SymbolRGS1
Full NameRegulator of G Protein Signaling 1
Chromosome1q31.2
FunctionThis activity rapidly terminates GPCR signaling by promoting Gα-GTP reassociation with Gβγ dimers, effectively serving as a molecular timer for GPCR signal transduction.
Primary ExpressionLymphoid tissues, Spleen, Lymph nodes, Blood leukocytes
Amino Acids206 aa
UniProt IDQ08169
NCBI Gene ID5996
Ensembl IDENSG00000190125
OMIM607070
GeneCardsRGS1
Human Protein AtlasRGS1
InteractionsATF3, VIM, RAB27A, COL4A1, ZFP36, HSPB1
KG Connections49 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RGS1 — AlphaFold Q08169 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

RGS1 — Regulator of G Protein Signaling 1

gene · 605 words

DCC

gene · 2541 words

KCNH1 Gene

gene · 862 words

GNB1 Gene - G Protein Subunit Beta 1

gene · 691 words

DLC1 Gene - Deleted in Liver Cancer 1

gene · 649 words

RGS2 Protein - Regulator of G Protein Signaling 2

protein · 620 words

Pathway Diagram

graph TD
    RGS1["<b>RGS1</b>"]
    Inflammation{"Inflammation"}
    RGS1 -->|"activates"| Inflammation
    Stroke{"Stroke"}
    RGS1 -->|"activates"| Stroke
    Als{"Als"}
    RGS1 -->|"activates"| Als
    Ischemia{"Ischemia"}
    RGS1 -->|"activates"| Ischemia
    Ms{"Ms"}
    RGS1 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    RGS1 -->|"inhibits"| Carcinoma
    RGS1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    RGS1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    RGS1 -->|"inhibits"| Tumor
    ZFP36["ZFP36"]
    RGS1 -->|"activates"| ZFP36
    HSPB1["HSPB1"]
    RGS1 -->|"activates"| HSPB1
    CH25H["CH25H"]
    RGS1 -->|"activates"| CH25H
    ANXA2["ANXA2"]
    ANXA2 -->|"activates"| RGS1
    ICAM1["ICAM1"]
    ICAM1 -->|"activates"| RGS1
    CD44["CD44"]
    CD44 -->|"activates"| RGS1
    HMOX1["HMOX1"]
    HMOX1 -->|"activates"| RGS1
    SPP1["SPP1"]
    SPP1 -->|"activates"| RGS1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| RGS1
    TIMP1["TIMP1"]
    TIMP1 -->|"activates"| RGS1
    LGALS3["LGALS3"]
    LGALS3 -->|"activates"| RGS1
    CD14["CD14"]
    CD14 -->|"activates"| RGS1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| RGS1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| RGS1
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| RGS1
    style RGS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Inflammationactivatesdisease0.65
Strokeactivatesdisease0.65
Alsactivatesdisease0.65
Ischemiaactivatesdisease0.65
Msactivatesdisease0.65

Incoming (30)

SourceRelationTypeStr
ANXA2activatesgene0.60
ICAM1activatesgene0.60
CD44activatesgene0.60
HMOX1activatesgene0.60
SPP1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found