Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RGS1 |
| Full Name | Regulator of G Protein Signaling 1 |
| Chromosome | 1q31.2 |
| Function | This activity rapidly terminates GPCR signaling by promoting Gα-GTP reassociation with Gβγ dimers, effectively serving as a molecular timer for GPCR signal transduction. |
| Primary Expression | Lymphoid tissues, Spleen, Lymph nodes, Blood leukocytes |
| Amino Acids | 206 aa |
| UniProt ID | Q08169 |
| NCBI Gene ID | 5996 |
| Ensembl ID | ENSG00000190125 |
| OMIM | 607070 |
| GeneCards | RGS1 |
| Human Protein Atlas | RGS1 |
| Interactions | ATF3, VIM, RAB27A, COL4A1, ZFP36, HSPB1 |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RGS1["<b>RGS1</b>"]
Inflammation{"Inflammation"}
RGS1 -->|"activates"| Inflammation
Stroke{"Stroke"}
RGS1 -->|"activates"| Stroke
Als{"Als"}
RGS1 -->|"activates"| Als
Ischemia{"Ischemia"}
RGS1 -->|"activates"| Ischemia
Ms{"Ms"}
RGS1 -->|"activates"| Ms
Carcinoma{"Carcinoma"}
RGS1 -->|"inhibits"| Carcinoma
RGS1 -->|"inhibits"| Ms
Cancer{"Cancer"}
RGS1 -->|"inhibits"| Cancer
Tumor{"Tumor"}
RGS1 -->|"inhibits"| Tumor
ZFP36["ZFP36"]
RGS1 -->|"activates"| ZFP36
HSPB1["HSPB1"]
RGS1 -->|"activates"| HSPB1
CH25H["CH25H"]
RGS1 -->|"activates"| CH25H
ANXA2["ANXA2"]
ANXA2 -->|"activates"| RGS1
ICAM1["ICAM1"]
ICAM1 -->|"activates"| RGS1
CD44["CD44"]
CD44 -->|"activates"| RGS1
HMOX1["HMOX1"]
HMOX1 -->|"activates"| RGS1
SPP1["SPP1"]
SPP1 -->|"activates"| RGS1
MICROGLIA["MICROGLIA"]
MICROGLIA -->|"activates"| RGS1
TIMP1["TIMP1"]
TIMP1 -->|"activates"| RGS1
LGALS3["LGALS3"]
LGALS3 -->|"activates"| RGS1
CD14["CD14"]
CD14 -->|"activates"| RGS1
ASTROCYTES["ASTROCYTES"]
ASTROCYTES -->|"activates"| RGS1
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"activates"| RGS1
CDKN2A["CDKN2A"]
CDKN2A -->|"inhibits"| RGS1
style RGS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| ATF3 | activates | gene | 0.60 |
| VIM | activates | gene | 0.60 |
| RAB27A | inhibits | gene | 0.60 |
| COL4A1 | inhibits | gene | 0.60 |
| ZFP36 | activates | gene | 0.60 |
| HSPB1 | activates | gene | 0.60 |
| CH25H | activates | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ANXA2 | activates | gene | 0.60 |
| ICAM1 | activates | gene | 0.60 |
| CD44 | activates | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| SPP1 | activates | gene | 0.60 |
| TIMP1 | activates | gene | 0.60 |
| LGALS3 | activates | gene | 0.60 |
| CD14 | activates | gene | 0.60 |
| CDKN2A | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | inhibits | gene | 0.60 |
| LZTS1 | inhibits | gene | 0.60 |
| DCC | inhibits | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| DLC1 | inhibits | gene | 0.60 |
| KCNH1 | associated_with | gene | 0.60 |
| NCAM1 | inhibits | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| PILRB | interacts_with | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||