gene

LZTS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LZTS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections
0Hypotheses
0Analyses
26Outgoing
12Incoming

Summary

LZTS1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, implicated in. Associated with Aging, Als, Alzheimer. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolLZTS1
Full NameLeucine Zipper Tumor Suppressor 1
Chromosome8
FunctionLeucine Zipper Tumor Suppressor 1 (LZTS1) is a putative tumor suppressor protein that contains multiple leucine zipper motifs and is involved in cell cycle regulation, cell migration, and neuronal dev
PathwaysApoptosis, Wnt, Mapk
Ensembl IDENSG00000061337
GeneCardsLZTS1
Human Protein AtlasLZTS1
Cell cycle regulationLZTS1 interacts with the ubiquitin-proteasome system to promote degradation of cyclin D1, controlling G1/S transition[@uno2022]
Actin cytoskeleton organizationLZTS1 localizes to the cytoskeleton and regulates cell migration and adhesion
Neuronal developmentIn the developing brain, LZTS1 regulates neurite outgrowth and axonal guidance through interactions with the actin cytoskeleton
BrainHigh expression in cerebral cortex, hippocampus (CA1-CA3 pyramidal cells), and cerebellum
Neuronal expressionLocalizes to dendritic shafts and growth cones during development
Cellular localizationCytoplasmic and cytoskeletal, with nuclear localization in dividing cells
Associated DiseasesAging, Als, Alzheimer, Dementia, Ms
InteractionsKCNK2, CD44, FGF10, KCNH1, NCAM1, RGS1
KG Connections38 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

LZTS1 — Leucine Zipper Tumor Suppressor 1

gene · 564 words

TrkB Protein

protein · 2959 words

DCC

gene · 2541 words

Genes

index · 271 words

Pathway Diagram

graph TD
    LZTS1["<b>LZTS1</b>"]
    Dementia{"Dementia"}
    LZTS1 -->|"associated with"| Dementia
    Aging{"Aging"}
    LZTS1 -->|"associated with"| Aging
    Alzheimer{"Alzheimer"}
    LZTS1 -->|"associated with"| Alzheimer
    Als{"Als"}
    LZTS1 -->|"associated with"| Als
    Ms{"Ms"}
    LZTS1 -->|"associated with"| Ms
    Carcinoma{"Carcinoma"}
    LZTS1 -->|"inhibits"| Carcinoma
    LZTS1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    LZTS1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    LZTS1 -->|"inhibits"| Tumor
    APOC2["APOC2"]
    LZTS1 -->|"associated with"| APOC2
    DCC["DCC"]
    LZTS1 -->|"associated with"| DCC
    KCNK2["KCNK2"]
    LZTS1 -->|"inhibits"| KCNK2
    COL4A1["COL4A1"]
    COL4A1 -->|"associated with"| LZTS1
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| LZTS1
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| LZTS1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| LZTS1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| LZTS1
    TNC["TNC"]
    TNC -->|"inhibits"| LZTS1
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| LZTS1
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| LZTS1
    WNT7A["WNT7A"]
    WNT7A -->|"associated with"| LZTS1
    AGING["AGING"]
    AGING -->|"associated with"| LZTS1
    APOC2 -->|"associated with"| LZTS1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| LZTS1
    style LZTS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

TargetRelationTypeStr
Dementiaassociated_withdisease0.65
Agingassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (12)

SourceRelationTypeStr
COL4A1associated_withgene0.60
CDKN2Aassociated_withgene0.60
TLR4inhibitsgene0.60
TNCinhibitsgene0.60
NTRK2inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found