Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LZTS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LZTS1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, implicated in. Associated with Aging, Als, Alzheimer. Connected to 39 entities in the SciDEX knowledge graph.
| Gene Symbol | LZTS1 |
| Full Name | Leucine Zipper Tumor Suppressor 1 |
| Chromosome | 8 |
| Function | Leucine Zipper Tumor Suppressor 1 (LZTS1) is a putative tumor suppressor protein that contains multiple leucine zipper motifs and is involved in cell cycle regulation, cell migration, and neuronal dev |
| Pathways | Apoptosis, Wnt, Mapk |
| Ensembl ID | ENSG00000061337 |
| GeneCards | LZTS1 |
| Human Protein Atlas | LZTS1 |
| Cell cycle regulation | LZTS1 interacts with the ubiquitin-proteasome system to promote degradation of cyclin D1, controlling G1/S transition[@uno2022] |
| Actin cytoskeleton organization | LZTS1 localizes to the cytoskeleton and regulates cell migration and adhesion |
| Neuronal development | In the developing brain, LZTS1 regulates neurite outgrowth and axonal guidance through interactions with the actin cytoskeleton |
| Brain | High expression in cerebral cortex, hippocampus (CA1-CA3 pyramidal cells), and cerebellum |
| Neuronal expression | Localizes to dendritic shafts and growth cones during development |
| Cellular localization | Cytoplasmic and cytoskeletal, with nuclear localization in dividing cells |
| Associated Diseases | Aging, Als, Alzheimer, Dementia, Ms |
| Interactions | KCNK2, CD44, FGF10, KCNH1, NCAM1, RGS1 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LZTS1["<b>LZTS1</b>"]
Dementia{"Dementia"}
LZTS1 -->|"associated with"| Dementia
Aging{"Aging"}
LZTS1 -->|"associated with"| Aging
Alzheimer{"Alzheimer"}
LZTS1 -->|"associated with"| Alzheimer
Als{"Als"}
LZTS1 -->|"associated with"| Als
Ms{"Ms"}
LZTS1 -->|"associated with"| Ms
Carcinoma{"Carcinoma"}
LZTS1 -->|"inhibits"| Carcinoma
LZTS1 -->|"inhibits"| Ms
Cancer{"Cancer"}
LZTS1 -->|"inhibits"| Cancer
Tumor{"Tumor"}
LZTS1 -->|"inhibits"| Tumor
APOC2["APOC2"]
LZTS1 -->|"associated with"| APOC2
DCC["DCC"]
LZTS1 -->|"associated with"| DCC
KCNK2["KCNK2"]
LZTS1 -->|"inhibits"| KCNK2
COL4A1["COL4A1"]
COL4A1 -->|"associated with"| LZTS1
CDKN2A["CDKN2A"]
CDKN2A -->|"associated with"| LZTS1
TLR4["TLR4"]
TLR4 -->|"inhibits"| LZTS1
CANCER["CANCER"]
CANCER -->|"inhibits"| LZTS1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| LZTS1
TNC["TNC"]
TNC -->|"inhibits"| LZTS1
NTRK2["NTRK2"]
NTRK2 -->|"inhibits"| LZTS1
PAK1["PAK1"]
PAK1 -->|"inhibits"| LZTS1
WNT7A["WNT7A"]
WNT7A -->|"associated with"| LZTS1
AGING["AGING"]
AGING -->|"associated with"| LZTS1
APOC2 -->|"associated with"| LZTS1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| LZTS1
style LZTS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| APOC2 | associated_with | gene | 0.60 |
| DCC | associated_with | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| DLC1 | associated_with | gene | 0.60 |
| KCNH1 | inhibits | gene | 0.60 |
| NCAM1 | inhibits | gene | 0.60 |
| RGS1 | inhibits | gene | 0.60 |
| RAB27A | inhibits | gene | 0.60 |
| COL4A1 | associated_with | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| COL4A1 | associated_with | gene | 0.60 |
| CDKN2A | associated_with | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | associated_with | gene | 0.60 |
| APOC2 | associated_with | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||