Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLL1 encodes Delta-Like 1, a Notch ligand crucial for neurogenesis, synaptic plasticity, and neural stem cell maintenance, with implications for Alzheimer's and Parkinson's disease
| Gene Symbol | DLL1 |
| Full Name | Delta-Like 1 |
| Chromosome | 6q27 |
| Function | encodes a transmembrane ligand of the Delta/Serrate/Lag-2 (DSL) family that activates Notch receptors through cell-cell contact. |
| Primary Expression | Brain (hippocampus, cortex, SVZ), neural stem cells, neurons, astrocytes |
| Molecular Weight | ~82 kDa |
| Amino Acids | 723 aa |
| Exons | 24 |
| Pathways | Notch, Notch signaling |
| UniProt ID | O00548 |
| NCBI Gene ID | 28514 |
| Ensembl ID | ENSG00000198719 |
| OMIM | 604552 |
| GeneCards | DLL1 |
| Human Protein Atlas | DLL1 |
| Associated Diseases | Als, Autism |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DLL1["<b>DLL1</b>"]
Als{"Als"}
DLL1 -->|"associated with"| Als
Autism{"Autism"}
DLL1 -->|"associated with"| Autism
DLL1 -->|"regulates"| Als
Ms{"Ms"}
DLL1 -->|"regulates"| Ms
Notch(["Notch"])
DLL1 -->|"associated with"| Notch
Lipid_Metabolism(["Lipid Metabolism"])
DLL1 -->|"therapeutic target"| Lipid_Metabolism
Sphingolipid(["Sphingolipid"])
DLL1 -->|"therapeutic target"| Sphingolipid
neurodegeneration["neurodegeneration"]
DLL1 -->|"implicated in"| neurodegeneration
NOS2["NOS2"]
NOS2 -->|"therapeutic target"| DLL1
CCL3["CCL3"]
CCL3 -->|"therapeutic target"| DLL1
ESR1["ESR1"]
ESR1 -->|"therapeutic target"| DLL1
ABCB1["ABCB1"]
ABCB1 -->|"therapeutic target"| DLL1
CIITA["CIITA"]
CIITA -->|"therapeutic target"| DLL1
style DLL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Depression | regulates | disease | 0.65 |
| BACE1 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| NLRP3 | regulates | gene | 0.60 |
| NOTCH1 | associated_with | gene | 0.60 |
| Notch signaling | participates_in | pathway | 0.60 |
| Notch | associated_with | pathway | 0.60 |
| Lipid Metabolism | therapeutic_target | pathway | 0.60 |
| Sphingolipid | therapeutic_target | pathway | 0.60 |
| Notch | regulates | pathway | 0.60 |
| Amyloid | regulates | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||