CIITA

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIITA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CIITA is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Als, Cancer, Inflammation. Connected to 43 entities in the SciDEX knowledge graph.

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graph TD
    CIITA["<b>CIITA</b>"]
    Cancer{"Cancer"}
    CIITA -->|"activates"| Cancer
    Ms{"Ms"}
    CIITA -->|"activates"| Ms
    Tumor{"Tumor"}
    CIITA -->|"activates"| Tumor
    CIITA -->|"expressed in"| Cancer
    Als{"Als"}
    CIITA -->|"regulates"| Als
    CIITA -->|"regulates"| Ms
    DNA["DNA"]
    CIITA -->|"activates"| DNA
    CD8["CD8"]
    CIITA -->|"activates"| CD8
    NPM1["NPM1"]
    CIITA -->|"activates"| NPM1
    IRF1["IRF1"]
    CIITA -->|"activates"| IRF1
    NLRC5["NLRC5"]
    CIITA -->|"activates"| NLRC5
    CXCR4["CXCR4"]
    CIITA -->|"expressed in"| CXCR4
    IRF1 -->|"binds"| CIITA
    NPM1 -->|"activates"| CIITA
    NLRC5 -->|"activates"| CIITA
    CD8 -->|"activates"| CIITA
    IRF1 -->|"activates"| CIITA
    CXCL12["CXCL12"]
    CXCL12 -->|"expressed in"| CIITA
    SRC["SRC"]
    SRC -->|"expressed in"| CIITA
    CD38["CD38"]
    CD38 -->|"expressed in"| CIITA
    CANCER["CANCER"]
    CANCER -->|"expressed in"| CIITA
    NOS2["NOS2"]
    NOS2 -->|"therapeutic target"| CIITA
    CCL3["CCL3"]
    CCL3 -->|"therapeutic target"| CIITA
    ESR1["ESR1"]
    ESR1 -->|"therapeutic target"| CIITA
    style CIITA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0