Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FISETIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FISETIN |
| Key Genes/Proteins | MTOR, CD28, TNF, NLRP3 |
| Related Diseases | PSORIASIS, MITOPHAGY, SENESCENCE, CANCER, INFLAMMATION |
| Related Pathways | NLRP3 INFLAMMASOME |
Knowledge base pages for this entity
graph TD
FISETIN["FISETIN"]
FISETIN -->|"targets"| Senescent_Cells["Senescent Cells"]
FISETIN -->|"modulates"| Cancer_Signaling_Pathways["Cancer Signaling Pathways"]
FISETIN -->|"inhibits"| MTOR["MTOR"]
FISETIN -->|"inhibits"| IL_17A["IL-17A"]
FISETIN -->|"inhibits"| senescent_cells["senescent cells"]
FISETIN -->|"treats"| Cancer["Cancer"]
FISETIN -->|"treats"| PSORIASIS["PSORIASIS"]| Target | Relation | Type | Str |
|---|---|---|---|
| PSORIASIS | treats | disease | 0.65 |
| MTOR | interacts_with | gene | 0.65 |
| PSORIASIS | protects_against | disease | 0.65 |
| CD28 | activates | gene | 0.65 |
| MITOPHAGY | treats | phenotype | 0.65 |
| MITOPHAGY | activates | phenotype | 0.65 |
| NLRP3 INFLAMMASOME | inhibits | pathway | 0.65 |
| MTOR | associated_with | gene | 0.45 |
| CANCER | associated_with | disease | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| PSORIASIS | associated_with | disease | 0.45 |
| QUERCETIN | associated_with | drug | 0.45 |
| TNF | associated_with | gene | 0.45 |
| NLRP3 | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SENESCENCE | associated_with | phenotype | 0.50 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| PSORIASIS | associated_with | disease | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| QUERCETIN | associated_with | drug | 0.45 |
| CD28 | associated_with | gene | 0.45 |
| CANCER | associated_with | disease | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| MITOPHAGY | associated_with | phenotype | 0.45 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||