Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FISETIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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FISETIN["FISETIN"]
FISETIN -->|"targets"| Senescent_Cells["Senescent Cells"]
FISETIN -->|"modulates"| Cancer_Signaling_Pathways["Cancer Signaling Pathways"]
FISETIN -->|"inhibits"| MTOR["MTOR"]
FISETIN -->|"inhibits"| IL_17A["IL-17A"]
FISETIN -->|"inhibits"| senescent_cells["senescent cells"]
FISETIN -->|"treats"| Cancer["Cancer"]
FISETIN -->|"treats"| PSORIASIS["PSORIASIS"]| Target | Relation | Type | Str |
|---|---|---|---|
| Amyloid-beta-induced neurotoxicity | protects_against | process | 0.95 |
| SOD1 | upregulates | gene | 0.90 |
| DLG4 | upregulates | gene | 0.85 |
| SYP | upregulates | gene | 0.85 |
| Senescent Cells | targets | cell_type | 0.85 |
| ACHE | downregulates | gene | 0.85 |
| Cancer Signaling Pathways | modulates | pathway | 0.80 |
| MTOR | downregulates | gene | 0.80 |
| PRKAA1 | upregulates | gene | 0.80 |
| Neuroinflammation | associated_with | process | 0.75 |
| senescent cells | inhibits | cell_type | 0.70 |
| Cancer | treats | disease | 0.70 |
| MITOPHAGY | treats | phenotype | 0.65 |
| MITOPHAGY | activates | phenotype | 0.65 |
| NLRP3 INFLAMMASOME | inhibits | pathway | 0.65 |
| PSORIASIS | protects_against | disease | 0.65 |
| CD28 | activates | gene | 0.65 |
| PSORIASIS | treats | disease | 0.65 |
| MTOR | interacts_with | gene | 0.65 |
| Inflammatory Disorders | treats | disease | 0.60 |
| Breast Cancer | targets | disease | 0.60 |
| Lung Cancer | targets | disease | 0.60 |
| TNF | associated_with | gene | 0.45 |
| NLRP3 | associated_with | gene | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| PSORIASIS | associated_with | disease | 0.45 |
| QUERCETIN | associated_with | drug | 0.45 |
| CANCER | associated_with | disease | 0.45 |
| MTOR | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SENESCENCE | associated_with | phenotype | 0.50 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| PSORIASIS | associated_with | disease | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| QUERCETIN | associated_with | drug | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| MITOPHAGY | associated_with | phenotype | 0.45 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
| CD28 | associated_with | gene | 0.45 |
| CANCER | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity