concept

GLS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

36Outgoing

15Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GLS1
Key Genes/Proteins	YAP, RUNX2, PIEZO1
Related Diseases	Tumor, Cancer, Als, Aging, Lung Cancer
Related Pathways	glutaminolysis

Wiki Pages (1)

Knowledge base pages for this entity

ARG1 Protein

protein · 1300 words

→

Pathway Diagram

graph TD
    GLS1["GLS1"]
    GLS1 -->|"regulates"| glutaminolysis["glutaminolysis"]
    GLS1 -->|"activates"| Tumor["Tumor"]
    GLS1 -->|"activates"| Cancer["Cancer"]
    GLS1 -->|"activates"| Als["Als"]
    GLS1 -->|"activates"| Aging["Aging"]
    GLS1 -->|"activates"| Lung_Cancer["Lung Cancer"]
    GLS1 -->|"activates"| ALS["ALS"]
    baicalein["baicalein"] -->|"inhibits"| GLS1
    YAP["YAP"] -->|"modulates"| GLS1
    Baicalein["Baicalein"] -->|"inhibits"| GLS1
    PIEZO1["PIEZO1"] -->|"regulates"| GLS1
    RUNX2["RUNX2"] -->|"activates"| GLS1
    AND["AND"] -->|"inhibits"| GLS1

Outgoing (36)

Target	Relation	Type	Str
glutaminolysis	regulates	pathway	0.72
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Lung Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
RUNX2	activates	gene	0.60
PIEZO1	regulates	gene	0.60
MTOR	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
YAP	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	inhibits	gene	0.60
Raf	activates	protein	0.60
App	activates	protein	0.60
GLS	inhibits	gene	0.60
Fibroblast	inhibits	cell_type	0.60
Rb	inhibits	protein	0.60
Ras	inhibits	protein	0.60
Collagen	inhibits	protein	0.60
LDHA	inhibits	gene	0.60
Glycolysis	inhibits	pathway	0.60
GSH	inhibits	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
LAT1	associated_with	gene	0.60

Incoming (15)

Source	Relation	Type	Str
baicalein	inhibits	drug	0.90
YAP	regulates	gene	0.64
YAP	activates	gene	0.60
PIEZO1	regulates	gene	0.60
RUNX2	activates	gene	0.60
AND	inhibits	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CANCER	activates	gene	0.60
MTOR	associated_with	gene	0.60
ATP	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
SLC1A5	regulates	gene	0.60
MYC	regulates	gene	0.60
GLS	activates	gene	0.60
ZO1	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found