Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC1A5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SLC1A5 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Cancer, Leukemia, Tumor. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | SLC1A5 |
| Full Name | Solute Carrier Family 1 Member 5 |
| Chromosome | 19q13.33 |
| Protein Type | Transporter |
| Function | is a sodium-dependent neutral amino acid transporter critical for cellular uptake of glutamine, alanine, serine, and cysteine[@amino2017]. |
| Primary Expression | many cancers where it supports rapid glutamine metabolism[@slc2020] |
| Subcellular Localization | Plasma membrane |
| Molecular Weight | 56 kDa |
| Amino Acids | 541 |
| Gene Type | Protein coding |
| Pathways | mTOR pathway |
| UniProt ID | P52802 |
| NCBI Gene ID | 6510 |
| Ensembl ID | ENSG00000105374 |
| OMIM | 109440 |
| GeneCards | SLC1A5 |
| Human Protein Atlas | SLC1A5 |
| Associated Diseases | neurodegeneration |
| Interactions | MYC, Rb, SMAD3, LYSOSOME, MTORC1, CANCER |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC1A5["SLC1A5<br/>Glutamine Transporter"]
STAT3["STAT3<br/>Transcription Factor"]
AUTOPHAGY_REG["AUTOPHAGY<br/>Regulatory Gene"]
MTORC1["MTORC1<br/>Protein Complex"]
MTOR_PATH["mTOR Pathway<br/>Growth Signaling"]
MITOCHONDRIA["MITOCHONDRIA<br/>Energy Production"]
OX_PHOS["Oxidative<br/>Phosphorylation"]
LYSOSOME["LYSOSOME<br/>Cellular Degradation"]
AUTOPHAGY_PATH["Autophagy<br/>Pathway"]
MYC["MYC<br/>Oncogene"]
NEURODEGENERATION["Neurodegeneration<br/>Disease Process"]
DNA_DAMAGE["DNA Damage<br/>Cellular Stress"]
GLUTAMINE["Glutamine<br/>Amino Acid"]
STAT3 -->|"transcriptionally regulates"| SLC1A5
AUTOPHAGY_REG -->|"upregulates"| SLC1A5
GLUTAMINE -->|"transported by"| SLC1A5
SLC1A5 -->|"activates"| MTORC1
SLC1A5 -->|"promotes"| MTOR_PATH
SLC1A5 -->|"enhances"| MITOCHONDRIA
SLC1A5 -->|"drives"| OX_PHOS
SLC1A5 -->|"activates"| LYSOSOME
SLC1A5 -->|"modulates"| AUTOPHAGY_PATH
SLC1A5 -->|"regulates"| MYC
SLC1A5 -->|"contributes to"| NEURODEGENERATION
SLC1A5 -->|"inhibits repair of"| DNA_DAMAGE
MTORC1 -->|"inhibits"| AUTOPHAGY_PATH
style SLC1A5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
style AUTOPHAGY_PATH fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style OX_PHOS fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style NEURODEGENERATION fill:#7d4200,stroke:#ff9800,stroke-width:2px
style DNA_DAMAGE fill:#ef5350,stroke:#f44336,stroke-width:2px
style STAT3 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style MYC fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style MTORC1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | therapeutic_target | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Leukemia | activates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Fibrosis | inhibits | disease | 0.65 |
| MYC | activates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| SMAD3 | inhibits | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Invasion | activates | pathway | 0.60 |
| Tumor Microenvironment | therapeutic_target | pathway | 0.60 |
| Immunotherapy | activates | pathway | 0.60 |
| DNA | inhibits | gene | 0.60 |
| Oxidative Phosphorylation | activates | pathway | 0.60 |
| Stem Cell | activates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| GLS1 | regulates | gene | 0.60 |
| LDHA | regulates | gene | 0.60 |
| Glycolysis | inhibits | pathway | 0.60 |
| TGF | inhibits | gene | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||