gene

GLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

Summary

GLS is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, regulates. Associated with Als, Ms, Myocardial Infarction. Connected to 19 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GLS
Full Name	Glutaminase (Kidney isoform)
Aliases	Page for GLS
Chromosome	2q32.2
Protein Type	Enzyme
Molecular Weight	~65 kDa
Amino Acids	598 aa
Pathways	Apoptosis
UniProt ID	O94925
NCBI Gene ID	2744
Ensembl ID	ENSG00000115419
OMIM	138280
GeneCards	GLS
Human Protein Atlas	GLS
Protein Size	598 amino acids
Associated Diseases	Als, Atherosclerosis, Ms
Interactions	BAX, Rb, ARG1, HK2, SLC1A5, P53
KG Connections	79 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GLS — AlphaFold O94925 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GLS["<b>GLS</b>"]
    Als{"Als"}
    GLS -->|"inhibits"| Als
    Ms{"Ms"}
    GLS -->|"associated with"| Ms
    BAX["BAX"]
    GLS -->|"inhibits"| BAX
    P53["P53"]
    GLS -->|"inhibits"| P53
    Apoptosis(["Apoptosis"])
    GLS -->|"regulates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    GLS -->|"implicated in"| neurodegeneration
    BCL_2["BCL-2"]
    BCL_2 -->|"inhibits"| GLS
    style GLS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
ammonia production	drives	process	0.90
Als	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Myocardial Infarction	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Ferroptosis	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
BAX	inhibits	gene	0.60
Rb	inhibits	protein	0.60
Rb	regulates	protein	0.60
L1CAM	associated_with	gene	0.60
ARG1	activates	gene	0.60
Nk Cell	therapeutic_target	cell_type	0.60
HK2	activates	gene	0.60
SLC1A5	activates	gene	0.60
P53	inhibits	gene	0.60
Apoptosis	regulates	pathway	0.60
G6PD	activates	gene	0.60
ROS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Fibroblast	inhibits	cell_type	0.60
Ras	inhibits	protein	0.60
Collagen	inhibits	protein	0.60
App	inhibits	protein	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Neuron	associated_with	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
HGF	therapeutic_target	gene	0.60
Epithelial	therapeutic_target	cell_type	0.60
Macrophage	therapeutic_target	cell_type	0.60
Fibroblast	therapeutic_target	cell_type	0.60
T Cell	therapeutic_target	cell_type	0.60
Neutrophil	therapeutic_target	cell_type	0.60
Toll-Like Receptor	regulates	pathway	0.60
Immune Response	expressed_in	pathway	0.60
Mitochondrial Function	expressed_in	pathway	0.60
T Cell	inhibits	cell_type	0.60
Actin	associated_with	protein	0.60
GLS1	activates	gene	0.60
microglia	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60

Incoming (25)

Source	Relation	Type	Str
SIRT5	modulates	gene	0.85
BAX	inhibits	gene	0.60
CD63	associated_with	gene	0.60
CD9	associated_with	gene	0.60
CD81	associated_with	gene	0.60
TLR4	activates	gene	0.60
CD4	associated_with	gene	0.60
SGCE	associated_with	gene	0.60
NLRP3	regulates	gene	0.60
SLC31A2	regulates	gene	0.60
RAB23	associated_with	gene	0.60
CDKN2A	regulates	gene	0.60
FASN	activates	gene	0.60
BCL-2	inhibits	gene	0.60
APOPTOSIS	regulates	gene	0.60
P53	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
GLS1	inhibits	gene	0.60
ROS	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
FDX1	associated_with	gene	0.60
ACC	activates	gene	0.60
ACLY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLS

Understanding Entity Pages

Summary

Wiki Pages (21)

GLS - Glutaminase

Parthanatos in Neurodegeneration

Neurotrophin Signaling Pathways in Neurodegeneration

dendritic-spines

Niemann-Pick Disease Type C (NPC)

CREB Signaling in Neurodegeneration

Synaptic Dysfunction in Neurodegeneration

Synaptic Plasticity Deficits in Neurodegeneration

Circadian Rhythm Modulation Therapy

Infantile Neuroaxonal Dystrophy (INAD)

Sleep-Wake Cycle

Histone Modification Pathways in Neurodegeneration

epigenetics-neurodegeneration

KCNQ2 Encephalopathy

Hippocampal CA3 Pyramidal Neurons in Epilepsy

Neuronal Migration

fabry-disease

Calcium Signaling Dysregulation in Alzheimer's Disease

Orexin/Hypocretin Signaling Pathway in Neurodegeneration