Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HCC |
| Key Genes/Proteins | TP53, ONCOGENES, ACVR2A, OGT, AKT, VEGFA |
| Related Diseases | NASH, oxidative_stress, inflammation |
| Related Pathways | angiogenesis, Wnt_pathway |
Knowledge base pages for this entity
graph TD
HCC["HCC"]
HCC -->|"regulates"| angiogenesis["angiogenesis"]
NASH["NASH"] -->|"causes"| HCC
OGT["OGT"] -->|"contributes to"| HCC
AKT["AKT"] -->|"activates"| HCC
oxidative_stress["oxidative_stress"] -->|"contributes to"| HCC
inflammation["inflammation"] -->|"contributes to"| HCC
Wnt_pathway["Wnt_pathway"] -->|"activates"| HCC
VEGFA["VEGFA"] -->|"implicated in"| HCC
EEF1A1["EEF1A1"] -->|"implicated in"| HCC| Target | Relation | Type | Str |
|---|---|---|---|
| TP53 | associated_with | gene | 0.70 |
| ONCOGENES | associated_with | gene | 0.70 |
| angiogenesis | regulates | biological_process | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NASH | causes | disease | 0.72 |
| ILC | associated_with | cell_type | 0.64 |
| ACVR2A | associated_with | gene | 0.64 |
| OGT | contributes_to | gene | 0.64 |
| AKT | activates | protein | 0.64 |
| oxidative_stress | contributes_to | phenotype | 0.56 |
| inflammation | contributes_to | phenotype | 0.56 |
| Wnt_pathway | activates | pathway | 0.56 |
| VEGFA | implicated_in | gene | 0.50 |
| EEF1A1 | implicated_in | gene | 0.50 |
| APOB | implicated_in | gene | 0.50 |
| MET | implicated_in | gene | 0.50 |
| MCL1 | implicated_in | gene | 0.50 |
| SF3B1 | implicated_in | gene | 0.50 |
| IDH1 | implicated_in | gene | 0.50 |
| SMARCA4 | implicated_in | gene | 0.50 |
| DNA | implicated_in | gene | 0.50 |
| LZTR1 | implicated_in | gene | 0.50 |
| MDM4 | implicated_in | gene | 0.50 |
| TERT | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||