gene

MDM4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

Summary

MDM4 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, implicated in. Associated with AD, ALI, ALS. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MDM4 (MDMX)
Full Name	MDM4 Proto-Oncogene
Chromosome	1q32.1
Function	MDM4 is a nuclear protein that contains a p53-binding domain and functions primarily as a transcriptional repressor[@toledo2007]:
Pathways	Epigenetic, Wnt signaling
UniProt ID	O15151
NCBI Gene ID	4193
Ensembl ID	ENSG00000198625
OMIM	602673
Associated Diseases	AD, ALI, AMI, Als, Cancer, Carcinoma
Interactions	JUN, MET, MCL1, VEGFA, SMARCA4, SF3B1
KG Connections	153 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MDM4 — AlphaFold O15151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MDM4["MDM4"] -->|"therapeutic target"| Cancer["Cancer"]
    MDM4["MDM4"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    MDM4["MDM4"] -->|"therapeutic target"| Ms["Ms"]
    MDM4["MDM4"] -->|"therapeutic target"| Als["Als"]
    MDM4["MDM4"] -->|"associated"| Als_1["Als"]
    MDM4["MDM4"] -->|"associated"| Cancer_2["Cancer"]
    IDH1["IDH1"] -->|"therapeutic target"| MDM4["MDM4"]
    VEGFA["VEGFA"] -->|"therapeutic target"| MDM4["MDM4"]
    SF3B1["SF3B1"] -->|"therapeutic target"| MDM4["MDM4"]
    TERT["TERT"] -->|"therapeutic target"| MDM4["MDM4"]
    style MDM4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (109)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.75
Leukemia	regulates	disease	0.75
Carcinoma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Melanoma	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Cancer	causes	disease	0.65
Inflammation	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
APOB	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
MCL1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
APOB	inhibits	gene	0.60
TERT	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
PARKIN	activates	gene	0.60
MDM2	activates	gene	0.60
GAIN	causes	gene	0.60
MDM2	interacts_with	gene	0.60
IDH1	therapeutic_target	gene	0.60
Vegf	therapeutic_target	protein	0.60
Rb	therapeutic_target	protein	0.60
PDGFRA	activates	gene	0.60

Incoming (44)

Source	Relation	Type	Str
IDH1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
APOB	associated_with	gene	0.60
EEF1A1	associated_with	gene	0.60
EEF1A1	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
APOB	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
MET	inhibits	gene	0.60
JUN	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
MCL1	inhibits	entity	0.60
MCL1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
AKT3	activates	gene	0.60
CDKN2A	activates	gene	0.60
DNA	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
DNA	inhibits	gene	0.60
P53	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
LZTR1	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
TERT	inhibits	gene	0.50
VEGFA	inhibits	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MDM4

Understanding Entity Pages

Summary

Wiki Pages (13)

MDM4 (MDMX)

eef1a1

SF3B1

Wnt Signaling Dysfunction in Neurodegenerative Diseases

RPL37 Gene - Ribosomal Protein L37

DNA Methylation

Wnt Signaling Modulation Therapy

PRMT5

Wnt Signaling Therapeutics: Investment Landscape Analysis

TP53 Protein (p53)

Wnt Pathway Modulation for Synaptic Resilience