gene

OGT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OGT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

1Hypotheses

2Analyses

50Outgoing

40Incoming

0Experiments

2Debates

Summary

Gene profile: OGT - O-GlcNAc N-acetylglucosaminyltransferase, the enzyme that adds O-GlcNAc to proteins, central to O-GlcNAcylation cycling

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🧬 Gene Info

Gene Symbol	OGT
Full Name	O-GlcNAc Transferase
Aliases	Gene profile: OGT
Chromosome	Xq13.1
Function	OGT catalyzes the transfer of a single GlcNAc from UDP-GlcNAc to the hydroxyl group of serine and threonine residues on target proteins
Primary Expression	neurons and glia:
Molecular Weight	110 kDa
Amino Acids	016 aa
Pathways	Apoptosis, Autophagy, Glycolysis, Immune Response, Inflammasome
UniProt ID	O15294
GeneCards	OGT
Human Protein Atlas	OGT
Transcription	O-GlcNAcylation of transcription factors (e.g., NF-κB, c-Myc, SP1) modulates their DNA binding, stability, and transcriptional activity (Wells et al., 2001).
Signal Transduction	O-GlcNAcylation of kinases and phosphatases (e.g., AKT, GSK-3β) influences signaling cascade activity (Gandy et al., 2011).
Proteostasis	O-GlcNAcylation affects protein aggregation, degradation, and autophagy (Rexach et al., 2012).
Associated Diseases	depression, neurodegeneration
Known Drugs/Compounds	ROS
Interactions	ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AND, APP, ASTROCYTES
SciDEX Hypotheses	O-GlcNAcylation at T212 competes with phosphorylat
KG Connections	144 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OGT — AlphaFold O15294 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OGT["OGT"]
    Carcinoma{"Carcinoma"}
    OGT -->|"contributes to"| Carcinoma
    Ms{"Ms"}
    OGT -->|"activates"| Ms
    Tumor{"Tumor"}
    OGT -->|"contributes to"| Tumor
    OGT -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    OGT -->|"activates"| Cancer
    Als{"Als"}
    OGT -->|"activates"| Als
    OGT -->|"regulates"| Als
    Inflammation{"Inflammation"}
    OGT -->|"activates"| Inflammation
    OGT -->|"regulates"| Ms
    Depression{"Depression"}
    OGT -->|"activates"| Depression
    FOXK2["FOXK2"]
    OGT -->|"regulates"| FOXK2
    HCC{"HCC"}
    OGT -->|"contributes to"| HCC
    ROS["ROS"]
    ROS -->|"activates"| OGT
    SLC7A11["SLC7A11"]
    SLC7A11 -->|"activates"| OGT
    STX17["STX17"]
    STX17 -->|"activates"| OGT
    FOXK2 -->|"activates"| OGT
    ULK1["ULK1"]
    ULK1 -->|"activates"| OGT
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"associated with"| OGT
    ENO1["ENO1"]
    ENO1 -->|"regulates"| OGT
    TLR["TLR"]
    TLR -->|"regulates"| OGT
    EXOSOMES["EXOSOMES"]
    EXOSOMES -->|"regulates"| OGT
    TRAF6["TRAF6"]
    TRAF6 -->|"regulates"| OGT
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"regulates"| OGT
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"regulates"| OGT
    style OGT fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (104)

Target	Relation	Type	Str
FOXK2	O-GlcNAcylates	protein	0.90
DEPRESSION	biomarker_for	disease	0.80
Alzheimer	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
tau pathology	regulates	phenotype	0.70
Tau O-GlcNAcylation at S400/T403	activates	phenotype	0.70
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	regulates	disease	0.65
Inflammation	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	contributes_to	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	activates	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
Infection	activates	disease	0.65
ALS	regulates	disease	0.65
Neuroblastoma	activates	disease	0.65
Ms	regulates	disease	0.65
Tumor	contributes_to	disease	0.65
Tumor	inhibits	disease	0.65
Depression	activates	disease	0.65
HCC	contributes_to	disease	0.64
FOXK2	regulates	protein	0.64
ferroptosis	associated_with	process	0.60
FOXK2	activates	gene	0.60
depression	causes	disease	0.60
APP	activates	gene	0.60
Ferroptosis	associated_with	pathway	0.60
depression	regulates	disease	0.60
TJP1	regulates	gene	0.60
Innate Immunity	inhibits	pathway	0.60
SLC7A11	implicated_in	gene	0.60
RIPK1	inhibits	gene	0.60
ULK1	activates	gene	0.60
Glycolysis	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
APOPTOSIS	regulates	gene	0.60
ferroptosis	participates_in	pathway	0.60
Autophagy	regulates	pathway	0.60
Glycolysis	activates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Necroptosis	inhibits	pathway	0.60
neuroinflammation	targets	disease	0.60
ENDOSOMES	activates	gene	0.60

Incoming (40)

Source	Relation	Type	Str
ROS	activates	drug	0.72
ALZHEIMER	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
ASTROCYTE	regulates	gene	0.60
MITOPHAGY	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ASTROCYTES	regulates	gene	0.60
SLC7A11	activates	gene	0.60
STX17	activates	gene	0.60
ULK1	activates	gene	0.60
ENO1	regulates	gene	0.60
TRAF6	regulates	gene	0.60
PTEN	activates	gene	0.60
PINK1	inhibits	gene	0.60
LC3	inhibits	gene	0.60
TAU	activates	gene	0.60
BRD4	activates	gene	0.60
EZH2	activates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
ASTROCYTE	causes	gene	0.60
DEPRESSION	activates	gene	0.60
FOXK2	implicated_in	gene	0.60
CANCER	inhibits	gene	0.60
TLR	regulates	gene	0.60
EXOSOMES	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
AMPK	regulates	entity	0.60
DEPRESSION	regulates	entity	0.60
NAD	inhibits	gene	0.60
LAMP1	activates	gene	0.60
NLRP3	activates	gene	0.60
CTSB	targets	gene	0.60
NLRP3	targets	gene	0.60
FOXK2	activates	gene	0.60
CTSB	activates	gene	0.60
BRG1	regulates	gene	0.55
GENES	co_discussed	gene	0.50
EZH2	co_expressed_with	gene	0.50
BRD4	co_expressed_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
O-GlcNAcylation at T212 competes with phosphorylation to red	0.380	alzheimers-disease-and-related-tauopathies	How can ESCRT or SNARE targeting achieve

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

Which specific post-translational modifications create druggable epitopes unique

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate was structured around this question but no literature was provided to

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate highlighted tau prion-like transmission but did not resolve how diffe

closed · Rounds: 4 · Score: 0.57 · 2026-04-15

Related Research

Hypotheses and analyses mentioning OGT in their description or question text

No additional research found

OGT