Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HLA-DRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HLA |
| Primary Expression | Ca1, Cortex |
| Pathways | Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response |
| GeneCards | HLA |
| Human Protein Atlas | HLA |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's disease, Cardiovascular |
| Interactions | CANCER, P53, IL-23, AND, GENES, HSPA1A |
| KG Connections | 307 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HLA_DRB1["HLA-DRB1"]
PICALM["PICALM"]
HLA_DRB1 -->|"expressed_in"| PICALM
EPHA1["EPHA1"]
HLA_DRB1 -->|"expressed_in"| EPHA1
SORL1["SORL1"]
HLA_DRB1 -->|"expressed_in"| SORL1
BIN1["BIN1"]
HLA_DRB1 -->|"expressed_in"| BIN1
CD2AP("CD2AP")
HLA_DRB1 -->|"expressed_in"| CD2AP
Genes["Genes"]
HLA_DRB1 -->|"expressed_in"| Genes
IMMUNE_RESPONSE(["IMMUNE RESPONSE"])
HLA_DRB1 -->|"expressed_in"| IMMUNE_RESPONSE
Endocytosis(["Endocytosis"])
HLA_DRB1 -->|"expressed_in"| Endocytosis
Proteins("Proteins")
HLA_DRB1 -->|"expressed_in"| Proteins
CD33["CD33"]
CD33 -->|"expressed_in"| HLA_DRB1
late{"late"}
late -->|"expressed_in"| HLA_DRB1
ABCA7["ABCA7"]
ABCA7 -->|"expressed_in"| HLA_DRB1
microglia["microglia"]
microglia -->|"expressed_in"| HLA_DRB1| Target | Relation | Type | Str |
|---|---|---|---|
| ds-db4a006ea647 | provides_data_for | dataset | 1.00 |
| PICALM | associated_with | gene | 0.60 |
| PICALM | expressed_in | gene | 0.50 |
| EPHA1 | expressed_in | gene | 0.50 |
| SORL1 | expressed_in | gene | 0.50 |
| BIN1 | expressed_in | gene | 0.50 |
| CD2AP | expressed_in | protein | 0.50 |
| IMMUNE RESPONSE | expressed_in | pathway | 0.50 |
| Endocytosis | expressed_in | pathway | 0.50 |
| Proteins | expressed_in | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-db4a006ea647 | data_in | dataset | 1.00 |
| CD33 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| endocytosis | associated_with | process | 0.60 |
| CD33 | expressed_in | gene | 0.50 |
| late | expressed_in | disease | 0.50 |
| ABCA7 | expressed_in | gene | 0.50 |
| microglia | expressed_in | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||