gene

EPHA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Eph Receptor A1, Alzheimer's disease protective gene involved in synaptic plasticity and immune regulation

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🧬 Gene Info

Gene Symbol	EPHA1
Full Name	Ephrin Type-A Receptor 1
Chromosome	7q34
Protein Type	Receptor
Function	Receptor Tyrosine Kinase Function: Binds ephrin-A ligands to initiate bidirectional signaling
Primary Expression	Neurons, Astrocytes, Microglia, T-cells
Molecular Weight	108 kDa
Amino Acids	976 aa
Exons	18
UniProt ID	P21709
NCBI Gene ID	2043
Ensembl ID	ENSG00000146938
OMIM	179610
GeneCards	EPHA1
Human Protein Atlas	EPHA1
Associated Diseases	Als, Alzheimer, Alzheimer's disease, COGNITIVE DECLINE, Inflammation, Ms
Interactions	ABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, App
KG Connections	167 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPHA1 — AlphaFold P21709 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EPHA1["EPHA1"]
    Ms{"Ms"}
    EPHA1 -->|"associated_with"| Ms
    Als{"Als"}
    EPHA1 -->|"associated_with"| Als
    Alzheimer{"Alzheimer"}
    EPHA1 -->|"associated_with"| Alzheimer
    CLU["CLU"]
    EPHA1 -->|"associated_with"| CLU
    CELF1["CELF1"]
    EPHA1 -->|"associated_with"| CELF1
    AND["AND"]
    EPHA1 -->|"associated_with"| AND
    GENES["GENES"]
    EPHA1 -->|"associated_with"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    EPHA1 -->|"associated_with"| ALZHEIMER_S_DISEASE
    MEF2C["MEF2C"]
    EPHA1 -->|"associated_with"| MEF2C
    PTK2B["PTK2B"]
    EPHA1 -->|"associated_with"| PTK2B
    HLA["HLA"]
    EPHA1 -->|"associated_with"| HLA
    FERMT2["FERMT2"]
    EPHA1 -->|"associated_with"| FERMT2
    RIN3["RIN3"]
    EPHA1 -->|"associated_with"| RIN3
    ZCWPW1["ZCWPW1"]
    EPHA1 -->|"associated_with"| ZCWPW1
    PLD3["PLD3"]
    PLD3 -->|"associated_with"| EPHA1

Outgoing (97)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:EPHA1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
BIN1	activates	gene	0.60
CD33	activates	gene	0.60
CD2AP	activates	gene	0.60
CLU	activates	gene	0.60
Endocytosis	associated_with	pathway	0.60
Neuroinflammatory	associated_with	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
PILRA	regulates	gene	0.60
PILRB	regulates	gene	0.60
RET	regulates	gene	0.60
TREM2	regulates	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HLA	associated_with	gene	0.60
MS4A	associated_with	gene	0.60
HLA	expressed_in	gene	0.60
MS4A	expressed_in	gene	0.60
microglia	expressed_in	cell_type	0.60
Alzheimer's disease	implicated_in	disease	0.60
CLU	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
MEF2C	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
ABCA7	activates	gene	0.60
ABCA7	associated_with	gene	0.60
CR1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
Rb	activates	protein	0.60
Rb	associated_with	protein	0.60
FERMT2	interacts_with	gene	0.60
INPP5D	interacts_with	gene	0.60
MEF2C	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60

Incoming (70)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:EPHA1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CLU	associated_with	gene	0.60
BIN1	expressed_in	gene	0.60
CD2AP	expressed_in	gene	0.60
CLU	expressed_in	gene	0.60
CR1	expressed_in	gene	0.60
ABCA7	co_discussed	gene	0.60
CD33	co_discussed	gene	0.60
ALZHEIMER	activates	gene	0.60
APOE	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
CD33	associated_with	gene	0.60
NME8	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
PLD3	associated_with	gene	0.60
CD33	interacts_with	gene	0.60
CELF1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
GENES	activates	gene	0.60
RNA	activates	gene	0.60
CLU	activates	gene	0.60
ABCA7	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CASS4	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
CD55	regulates	gene	0.60
FERMT2	activates	gene	0.60
CELF1	activates	gene	0.60
ABCA7	activates	gene	0.60
CASS4	activates	gene	0.60
APOE	activates	gene	0.60
CD2AP	activates	gene	0.60
BIN1	activates	gene	0.60
CD33	regulates	gene	0.60
ZCWPW1	activates	gene	0.60
CD2AP	implicated_in	gene	0.60
APOC1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
LNCRNA	activates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity