gene

IFNAR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IFNAR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

20Outgoing

16Incoming

0Experiments

Summary

IFNAR2 encodes the signal-transducing component of the type I interferon receptor, mediating JAK-STAT signaling with roles in neuroinflammation and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	IFNAR2
Full Name	Interferon Alpha and Beta Receptor Subunit 2
Chromosome	21q22.1
Primary Expression	neurons, microglia, astrocytes, and [oligodendrocytes](/entiti
Amino Acids	505 aa
Pathways	JAK-STAT signaling
UniProt ID	[P48551](https://www.uniprot.org/uniprot/P48551)
NCBI Gene ID	3455
Ensembl ID	ENSG00000159197
OMIM	206550
GeneCards	IFNAR2
Human Protein Atlas	IFNAR2
RefSeq	NM_001034200
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	C1Q, PSEN1, STAT2, VIRAL INFECTIONS, ALZHEIMER
KG Connections	36 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IFNAR2["<b>IFNAR2</b>"]
    Alzheimer["Alzheimer"]
    IFNAR2 -->|"regulates"| Alzheimer
    Inflammation["Inflammation"]
    IFNAR2 -->|"regulates"| Inflammation
    C1Q["C1Q"]
    IFNAR2 -->|"regulates"| C1Q
    ASTROCYTE["ASTROCYTE"]
    IFNAR2 -->|"regulates"| ASTROCYTE
    ALZHEIMER["ALZHEIMER"]
    IFNAR2 -->|"regulates"| ALZHEIMER
    TNF["TNF"]
    IFNAR2 -->|"regulates"| TNF
    STAT2["STAT2"]
    IFNAR2 -->|"expressed in"| STAT2
    PSEN1["PSEN1"]
    IFNAR2 -->|"regulates"| PSEN1
    ASTROCYTES["ASTROCYTES"]
    IFNAR2 -->|"regulates"| ASTROCYTES
    Jak_Stat["Jak-Stat"]
    IFNAR2 -->|"expressed in"| Jak_Stat
    Astrocyte["Astrocyte"]
    IFNAR2 -->|"regulates"| Astrocyte
    JAK["JAK"]
    IFNAR2 -->|"expressed in"| JAK
    VIRAL_INFECTIONS["VIRAL INFECTIONS"]
    VIRAL_INFECTIONS -->|"activates"| IFNAR2
    C1Q["C1Q"]
    C1Q -->|"regulates"| IFNAR2
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"regulates"| IFNAR2
    PSEN1["PSEN1"]
    PSEN1 -->|"regulates"| IFNAR2
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"regulates"| IFNAR2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| IFNAR2
    STAT2["STAT2"]
    STAT2 -->|"expressed in"| IFNAR2
    AND["AND"]
    AND -->|"expressed in"| IFNAR2
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"regulates"| IFNAR2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| IFNAR2
    Astrocyte["Astrocyte"]
    IFNAR2 -->|"expressed in"| Astrocyte
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| IFNAR2
    C1Q["C1Q"]
    C1Q -->|"activates"| IFNAR2
    PSEN1["PSEN1"]
    PSEN1 -->|"activates"| IFNAR2
    neurodegeneration["neurodegeneration"]
    IFNAR2 -->|"implicated in"| neurodegeneration

Outgoing (20)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
C1Q	regulates	gene	0.60
TNF	regulates	gene	0.60
STAT2	expressed_in	gene	0.60
PSEN1	regulates	gene	0.60
Rb	regulates	protein	0.60
PSEN	expressed_in	gene	0.60
TBK1	implicated_in	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
Jak-Stat	expressed_in	pathway	0.60
Astrocyte	regulates	cell_type	0.60
JAK	expressed_in	gene	0.60
Cytokine	regulates	protein	0.60
JAK-STAT signaling	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
Astrocyte	expressed_in	cell_type	0.55
Jak-Stat	inhibits	pathway	0.50

Incoming (16)

Source	Relation	Type	Str
C1Q	regulates	gene	0.60
PSEN1	regulates	gene	0.60
STAT2	expressed_in	gene	0.60
TNF	regulates	gene	0.60
IFIH1	implicated_in	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
ASTROCYTE	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	expressed_in	gene	0.60
ASTROCYTES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
C1Q	activates	gene	0.50
PSEN1	activates	gene	0.50
STAT2	inhibits	gene	0.50
ALZHEIMER	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IFNAR2

Understanding Entity Pages

Summary

Wiki Pages (12)

IFNAR2 — Interferon Alpha Receptor 2

IL28B (Interleukin 28B)

Interferon Signaling in Neurodegeneration

STAT4 Gene

TYK2 Protein — Tyrosine Kinase 2

IFNAR1 — Interferon Alpha Receptor 1

Type I Interferon Modulation Therapy for Neurodegeneration

STAT2 Gene - Signal Transducer and Activator of Transcription 2

IFNAR2 Protein — Interferon Alpha Receptor 2

IFNAR1 Protein — Interferon Alpha Receptor 1

Proteins