concept

IL-33

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-33: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

2Hypotheses

1Analyses

40Outgoing

19Incoming

0Experiments

1Debates

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💡 Concept Info

Name	IL-33
Key Genes/Proteins	Actin, AGING, AND, CANCER, Chemokine, CMKLR1
Related Diseases	Aging, Als, ALS, ASTHMA, Cancer
Related Pathways	Chemerin-Cmklr1 Axis, Cholesterol

Wiki Pages (1)

Knowledge base pages for this entity

IL-33/ST2 Modulation Therapy for Neurodegeneration

therapeutic · 778 words

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Pathway Diagram

graph TD
    IL_33["IL-33"]
    IL_33 -->|"activates"| Type_2_Innate_Immunity["Type 2 Innate Immunity"]
    IL_33 -->|"activates"| Cancer["Cancer"]
    IL_33 -->|"activates"| Aging["Aging"]
    IL_33 -->|"activates"| Obesity["Obesity"]
    IL_33 -->|"target for"| Als["Als"]
    IL_33 -->|"inhibits"| Inflammation["Inflammation"]
    IL_33 -->|"activates"| CMKLR1["CMKLR1"]
    IL_33 -->|"activates"| CANCER["CANCER"]
    Beige_Adipocyte["Beige Adipocyte"] -->|"expressed in"| IL_33
    AGING["AGING"] -->|"activates"| IL_33
    AND["AND"] -->|"activates"| IL_33
    CYTOKINES["CYTOKINES"] -->|"interacts"| IL_33
    INFLAMMATION["INFLAMMATION"] -->|"inhibits"| IL_33
    TSLP["TSLP"] -->|"inhibits"| IL_33
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"interacts"| IL_33

Outgoing (40)

Target	Relation	Type	Str
Type 2 Innate Immunity	activates	process	0.85
Inguinal White Adipose Tissue	expressed_in	cell_type	0.80
neuroinflammation	regulates	process	0.70
Inflammation	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Obesity	activates	disease	0.65
CMKLR1	activates	gene	0.60
AND	activates	gene	0.60
Immune Response	activates	pathway	0.60
CANCER	activates	gene	0.60
Innate Immunity	regulates	pathway	0.60
CRH	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
Interleukin	associated_with	protein	0.60
Cytokine	interacts_with	protein	0.60
Cholesterol	activates	pathway	0.60
T Cell	activates	cell_type	0.60
TSLP	associated_with	gene	0.60
Oxidative Stress	interacts_with	pathway	0.60
AND	contributes_to	gene	0.60
AGING	activates	gene	0.60
TSLP	therapeutic_target	gene	0.60
Epithelial	contributes_to	cell_type	0.60
Mast Cell	activates	cell_type	0.60
Actin	inhibits	protein	0.60
Interleukin	activates	protein	0.60
Cytokine	contributes_to	protein	0.60
Rb	inhibits	protein	0.60
CYTOKINES	contributes_to	gene	0.60
Chemokine	activates	protein	0.60
INFLAMMATION	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
Mast Cell	expressed_in	cell_type	0.55
T Cell	expressed_in	cell_type	0.55
MAST CELLS	activates	cell_type	0.35
INNATE IMMUNITY	activates	process	0.35
INNATE IMMUNITY	regulates	process	0.35

Incoming (19)

Source	Relation	Type	Str
Beige Adipocyte	expressed_in	cell_type	0.85
Chemerin-Cmklr1 Axis	modulates	mechanism	0.85
Beige Adipocyte	associated_with	cell_type	0.75
NLRP3	part_of	gene	0.70
CMKLR1	activates	gene	0.60
CRH	associated_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
AGING	activates	gene	0.60
CANCER	activates	gene	0.60
TSLP	therapeutic_target	gene	0.60
TSLP	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TSLP	inhibits	gene	0.60
CYTOKINES	inhibits	protein	0.35
ASTHMA	inhibits	disease	0.35
COPD	inhibits	disease	0.35
ASTHMA	therapeutic_target	disease	0.35
COPD	therapeutic_target	disease	0.35

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e
IL-33/ST2 Axis Augmentation for Synaptic Protection	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation Biomarker Panel for Early AD Detection

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.105

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the optimal blood-based biomarker panel combining established markers (G

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning IL-33 in their description or question text

No additional research found