disease

COPD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COPD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

436Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	MMP9, FEATURE DEGS, PYCARD, 6 GENES, PARKIN, SQSTM1, NLRP3, PINK1
Therapeutic Agents	BYF, Anti-Inflammatory Therapy
KG Connections	309 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Utilisation of Health Services and Quality of Life in Atypical Parkinsonian Syndromes (NCT06645626)

clinical · 3029 words

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Pathway Diagram

graph TD
    COPD["COPD"] -->|"associated"| Persistent_Cough["Persistent Cough"]
    style Persistent_Cough fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"associated"| Sputum_Production["Sputum Production"]
    style Sputum_Production fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"associated"| Sarcopenia["Sarcopenia"]
    style Sarcopenia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"interacts"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style FRONTOTEMPORAL_DEMENTIA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| ROS["ROS"]
    style ROS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    style ENDOPLASMIC_RETICULUM fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Chronic_Inflammation["Chronic Inflammation"] -->|"associated"| COPD["COPD"]
    style Chronic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Neutrophilic_Inflammation["Neutrophilic Inflammation"] -->|"contributes to"| COPD["COPD"]
    style Neutrophilic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"therapeutic target"| COPD["COPD"]
    style STAT3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    HUB_GENES["HUB GENES"] -->|"risk factor for"| COPD["COPD"]
    style HUB_GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Cytokines["Cytokines"] -->|"contributes to"| COPD["COPD"]
    style Cytokines fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style COPD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (173)

Target	Relation	Type	Str
Airflow Limitation	causes	phenotype	0.95
Persistent Cough	associated_with	phenotype	0.90
Sputum Production	associated_with	phenotype	0.90
Persistent Cough	causes	phenotype	0.90
Sputum Production	causes	phenotype	0.90
Sarcopenia	associated_with	disease	0.70
PYROPTOSIS	implicated_in	phenotype	0.55
INFLAMMATION	interacts_with	process	0.50
SYNUCLEIN	activates	concept	0.50
Reactive Oxygen Species	activates	process	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
Proteins	activates	protein	0.50
TSLP	inhibits	concept	0.50
TSLP	associated_with	concept	0.50
NEUTROPHIL	associated_with	cell_type	0.50
NEUTROPHIL	regulates	cell_type	0.50
NEUTROPHIL	activates	cell_type	0.50
GBA	associated_with	gene	0.45
JNK	associated_with	gene	0.45
RB1	associated_with	gene	0.45
ATM	associated_with	gene	0.45
CTSD	co_discussed	gene	0.40
HEPSIN	co_discussed	protein	0.40
DDIT3	co_discussed	gene	0.40
CHOP	co_discussed	gene	0.40
DNA	co_discussed	protein	0.40
DISC1	co_discussed	gene	0.40
DNM1L	co_discussed	gene	0.40
DRP1	co_discussed	protein	0.40
EIF2AK3	co_discussed	gene	0.40
PERK	co_discussed	protein	0.40
EIF2S1	co_discussed	gene	0.40
EIF2Α	co_discussed	protein	0.40
EMD	co_discussed	gene	0.40
EPAS1	co_discussed	gene	0.40
ERN1	co_discussed	gene	0.40
IRE1	co_discussed	protein	0.40
GNAL	co_discussed	gene	0.40
FTD	co_discussed	disease	0.40
FRONTOTEMPORAL DEMENTIA	co_discussed	disease	0.40
FUNDC1	co_discussed	gene	0.40
G3BP1	co_discussed	gene	0.40
GBA	co_discussed	gene	0.40
HIF1A	co_discussed	protein	0.40
LGALS3	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
LMNA	co_discussed	gene	0.40
MAPK8	co_discussed	gene	0.40
JNK	co_discussed	protein	0.40
MAP1LC3B	co_discussed	gene	0.40

Incoming (263)

Source	Relation	Type	Str
Chronic Inflammation	associated_with	process	0.95
Neutrophilic Inflammation	contributes_to	process	0.95
STAT3	therapeutic_target	protein	0.90
Inflammation	involved_in	process	0.90
Hub Genes (9 Novel)	biomarker_for	biomarker	0.90
HUB GENES	risk_factor_for	gene	0.85
Hub Genes (2 Genes)	risk_factor_for	biomarker	0.85
Cytokines	contributes_to	biological_process	0.80
FEATURE DEGS	causes	gene	0.80
CHIP	associated_with	disease	0.75
Anti-Inflammatory Therapy	treats	drug	0.75
6 GENES	causes	gene	0.75
BYF	treats	drug	0.72
Protease-Antiprotease Imbalance	contributes_to	biological_process	0.70
Epigenetic Factors	contributes_to	biological_process	0.70
MMP9	associated_with	protein	0.64
PYCARD	biomarker_for	gene	0.60
NEUTROPHILS	expressed_in	cell_type	0.55
AMPK	activates	gene	0.50
AMBRA1	activates	protein	0.50
PERK	activates	gene	0.50
HIF1A	activates	gene	0.50
ABCD3	activates	gene	0.50
Autophagy	activates	process	0.50
MITOCHONDRIA	activates	cell_type	0.50
SNCA	activates	gene	0.50
STING1	activates	protein	0.50
G3BP1	activates	gene	0.50
EIF2AK3	activates	gene	0.50
DDIT3	activates	gene	0.50
CTSD	activates	gene	0.50
MAPK8	activates	gene	0.50
RIPK3	activates	gene	0.50
OPTN	activates	gene	0.50
PARKIN	activates	gene	0.50
LMNA	activates	gene	0.50
NDP52	activates	gene	0.50
PTEN	activates	gene	0.50
FIP200	activates	gene	0.50
FAM134B	activates	gene	0.50
PINK1	activates	gene	0.50
ERN1	activates	gene	0.50
CANX	activates	gene	0.50
BNIP3	activates	gene	0.50
SQSTM1	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
SESN2	activates	gene	0.50
DISC1	activates	gene	0.50
PRKN	activates	gene	0.50
TAX1BP1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

COPD

Understanding Entity Pages

Wiki Pages (20)

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Lupin Pharmaceuticals

NIH Drug Repurposing Program for Neurodegenerative Diseases

jnk-p38-mapk-parkinsons

Utilisation of Health Services and Quality of Life in Atypical Parkinsonian Syndromes (NCT06645626)

rivastigmine

CHRM3 Gene

MAP3K6 Gene

neflamapimod-psp

Cellular Senescence Therapeutic Targeting

Galectin-3 Modulation Therapy

PDE4 Inhibitor PD Trial

nct05266417-nose-pd

ANO9 — Anoctamin 9

IL1RL1 Gene

p2x7-receptor-neurons

Donepezil

CXCL1