IKBKG

Understanding Entity Pages

This page aggregates everything SciDEX knows about IKBKG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

IKBKG (IκB Kinase Gamma/NEMO) encodes the regulatory subunit of the IKK complex, essential for NF-κB activation. Critical for neuroinflammation in Alzheimer's and Parkinson's disease, immune responses, and cell survival. Mutations cause Incontinentia Pigmenti and immunodeficiency syndromes.

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graph TD
    IKBKG["<b>IKBKG</b>"]
    Inflammation{"Inflammation"}
    IKBKG -->|"activates"| Inflammation
    Als{"Als"}
    IKBKG -->|"activates"| Als
    IKBKG -->|"regulates"| Als
    Ms{"Ms"}
    IKBKG -->|"regulates"| Ms
    Epilepsy{"Epilepsy"}
    IKBKG -->|"expressed in"| Epilepsy
    IKBKG -->|"expressed in"| Ms
    Lysosomal_Degradation(["Lysosomal Degradation"])
    IKBKG -->|"activates"| Lysosomal_Degradation
    PSMB8["PSMB8"]
    IKBKG -->|"regulates"| PSMB8
    Nf__b(["Nf-Kappab"])
    IKBKG -->|"activates"| Nf__b
    TLR2["TLR2"]
    IKBKG -->|"expressed in"| TLR2
    TLR1["TLR1"]
    IKBKG -->|"expressed in"| TLR1
    HMGB1["HMGB1"]
    IKBKG -->|"expressed in"| HMGB1
    OTULIN["OTULIN"]
    OTULIN -->|"activates"| IKBKG
    NFKB["NFKB"]
    NFKB -->|"activates"| IKBKG
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"regulates"| IKBKG
    TREX1["TREX1"]
    TREX1 -->|"regulates"| IKBKG
    TLR4["TLR4"]
    TLR4 -->|"expressed in"| IKBKG
    IL1B["IL1B"]
    IL1B -->|"expressed in"| IKBKG
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"expressed in"| IKBKG
    TLR3["TLR3"]
    TLR3 -->|"expressed in"| IKBKG
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    PROINFLAMMATORY_CYTOKINES -->|"expressed in"| IKBKG
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| IKBKG
    RAGE["RAGE"]
    RAGE -->|"expressed in"| IKBKG
    IRAK2["IRAK2"]
    IRAK2 -->|"expressed in"| IKBKG
    style IKBKG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0