gene

PSMB8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMB8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

45Outgoing

17Incoming

Summary

PSMB8 is a gene implicated in neurodegeneration research. Key relationships include: activates, causes, regulates. Associated with Aging, Als, Inflammation. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PSMB8
Full Name	Proteasome Subunit Beta 8
Function	is a member of the proteasome family and encodes the β5i subunit, which is primarily expressed in immune cells and becomes the catalytically active component of the immunoproteasome.
Primary Expression	immune cells and becomes the catalytically active component of the immunoproteasome
Molecular Weight	30.3 kDa
Amino Acids	276 aa
Pathways	Nf-Κb
Ensembl ID	ENSG00000240065
GeneCards	PSMB8
Human Protein Atlas	PSMB8
Associated Diseases	Inflammation, Multiple Sclerosis, Neurodegeneration
Interactions	ASTROCYTES, ALPHA-SYNUCLEIN, ASTROCYTE, AUTOPHAGY, NEURON, AND
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PSMB8["<b>PSMB8</b>"]
    Als{"Als"}
    PSMB8 -->|"regulates"| Als
    Ms{"Ms"}
    PSMB8 -->|"regulates"| Ms
    Nf__b(["Nf-Kappab"])
    PSMB8 -->|"regulates"| Nf__b
    neurodegeneration["neurodegeneration"]
    PSMB8 -->|"implicated in"| neurodegeneration
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"associated with"| PSMB8
    TREX1["TREX1"]
    TREX1 -->|"associated with"| PSMB8
    IKBKG["IKBKG"]
    IKBKG -->|"regulates"| PSMB8
    style PSMB8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
NEURON	activates	gene	0.70
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	causes	disease	0.65
Multiple Sclerosis	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Neurodegeneration	degrades	disease	0.65
Ferroptosis	degrades	disease	0.65
Multiple Sclerosis	degrades	disease	0.65
Rb	causes	protein	0.60
SAMHD1	associated_with	gene	0.60
TREX1	associated_with	gene	0.60
Nf-Κb	regulates	pathway	0.60
ASTROCYTES	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Complement	activates	pathway	0.60
Chaperone	activates	pathway	0.60
INFLAMMATION	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
Ferroptosis	causes	pathway	0.60
Glycolysis	causes	pathway	0.60
Proteasome	activates	pathway	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
AND	activates	gene	0.60
Neuron	activates	cell_type	0.60
NEURODEGENERATION	causes	gene	0.60
PFKFB3	therapeutic_target	gene	0.60
Glycolysis	degrades	pathway	0.60
Neuron	degrades	cell_type	0.60
Interferon	degrades	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.55
NEURONS	activates	concept	0.50
PFKFB3	protects_against	protein	0.50
Neuron	protects_against	cell_type	0.50
NEURONS	protects_against	concept	0.50

Incoming (17)

Source	Relation	Type	Str
SAMHD1	associated_with	gene	0.60
TREX1	associated_with	gene	0.60
IKBKG	regulates	gene	0.60
TLR2	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
PFKFB3	protects_against	gene	0.60
INFLAMMATION	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
PFKFB3	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
FERROPTOSIS	degrades	gene	0.60
PFKFB3	inhibits	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PSMB8

Understanding Entity Pages

Summary

Wiki Pages (13)

PSMB8

Advanced Proteolysis and Ubiquitin System Targeting in CBS/PSP

Proteasomal Pathway in Neurodegeneration

Disease-Associated Astrocytes (DAA)

PSMB9 Protein

PSMB7

PSMB9

PSMB10

PSMB8 Protein

SAMHD1 — SAM and HD Domain Containing Metal Dependent Hydrolase 1

PSMB10 Protein

Proteins

Genes

Pathway Diagram

Outgoing (45)

Incoming (17)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)