Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LRP4 is a transmembrane receptor essential for neuromuscular junction formation, synapse development, and implicated in Alzheimer's disease, myasthenia gravis, and congenital myasthenic syndromes.
| Gene Symbol | LRP4 |
| Full Name | Low Density Lipoprotein Receptor-Related Protein 4 |
| Aliases | Page for LRP4 Protein |
| Chromosome | 11p11.2 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cell membrane (postsynaptic), endosomes |
| Molecular Weight | ~195 kDa |
| Amino Acids | 1725 amino acids |
| Exons | 33 |
| Gene Type | Protein coding |
| Pathways | Wnt signaling, Wnt |
| UniProt ID | Q9NZU0 |
| NCBI Gene ID | 4038 |
| Ensembl ID | ENSG00000134538 |
| OMIM | 604270 |
| GeneCards | LRP4 |
| Human Protein Atlas | LRP4 |
| Associated Diseases | ALS, Aging, Atherosclerosis, Cancer, Cardiovascular |
| Interactions | WNT, CANCER, PAH |
| KG Connections | 70 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
LRP4["<b>LRP4</b>"]
Cancer{"Cancer"}
LRP4 -->|"associated with"| Cancer
Neurodegeneration{"Neurodegeneration"}
LRP4 -->|"associated with"| Neurodegeneration
Cardiovascular{"Cardiovascular"}
LRP4 -->|"associated with"| Cardiovascular
Als{"Als"}
LRP4 -->|"associated with"| Als
Aging{"Aging"}
LRP4 -->|"associated with"| Aging
Hypertension{"Hypertension"}
LRP4 -->|"associated with"| Hypertension
Atherosclerosis{"Atherosclerosis"}
LRP4 -->|"associated with"| Atherosclerosis
Stroke{"Stroke"}
LRP4 -->|"associated with"| Stroke
Ms{"Ms"}
LRP4 -->|"associated with"| Ms
Heart_Failure{"Heart Failure"}
LRP4 -->|"associated with"| Heart_Failure
Ftd{"Ftd"}
LRP4 -->|"associated with"| Ftd
ALS{"ALS"}
LRP4 -->|"associated with"| ALS
LRP8["LRP8"]
LRP8 -->|"associated with"| LRP4
LRP5["LRP5"]
LRP5 -->|"associated with"| LRP4
LRP1["LRP1"]
LRP1 -->|"associated with"| LRP4
LRP2["LRP2"]
LRP2 -->|"associated with"| LRP4
LRP1B["LRP1B"]
LRP1B -->|"associated with"| LRP4
PAH["PAH"]
PAH -->|"associated with"| LRP4
LDLR["LDLR"]
LDLR -->|"associated with"| LRP4
LDL["LDL"]
LDL -->|"associated with"| LRP4
STROKE["STROKE"]
STROKE -->|"associated with"| LRP4
REELIN["REELIN"]
REELIN -->|"associated with"| LRP4
AND["AND"]
AND -->|"associated with"| LRP4
AGING["AGING"]
AGING -->|"associated with"| LRP4
style LRP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Heart Failure | associated_with | disease | 0.65 |
| Ftd | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Hypertension | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| PAH | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LRP5 | associated_with | gene | 0.60 |
| LRP1 | associated_with | gene | 0.60 |
| LRP8 | associated_with | gene | 0.60 |
| LRP2 | associated_with | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| LRP1B | associated_with | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| CD4 | therapeutic_target | gene | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| LDL | associated_with | gene | 0.60 |
| Lipid Metabolism | activates | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| Endothelial | associated_with | cell_type | 0.60 |
| Monocyte | associated_with | cell_type | 0.60 |
| App | associated_with | protein | 0.60 |
| APOER2 | associated_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRP8 | associated_with | gene | 0.60 |
| LRP5 | associated_with | gene | 0.60 |
| LRP1 | associated_with | gene | 0.60 |
| LRP2 | associated_with | gene | 0.60 |
| LRP1B | associated_with | gene | 0.60 |
| PAH | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| PAH | activates | gene | 0.60 |
| LDL | associated_with | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| APOER2 | associated_with | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| LDLR | co_mentioned | gene | 0.40 |
| LRP1 | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||