gene

LRP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections
0Hypotheses
0Analyses
50Outgoing
18Incoming

Summary

LRP4 is a transmembrane receptor essential for neuromuscular junction formation, synapse development, and implicated in Alzheimer's disease, myasthenia gravis, and congenital myasthenic syndromes.

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🧬 Gene Info
Gene SymbolLRP4
Full NameLow Density Lipoprotein Receptor-Related Protein 4
AliasesPage for LRP4 Protein
Chromosome11p11.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationCell membrane (postsynaptic), endosomes
Molecular Weight~195 kDa
Amino Acids1725 amino acids
Exons33
Gene TypeProtein coding
PathwaysWnt signaling, Wnt
UniProt IDQ9NZU0
NCBI Gene ID4038
Ensembl IDENSG00000134538
OMIM604270
GeneCardsLRP4
Human Protein AtlasLRP4
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsWNT, CANCER, PAH
KG Connections70 knowledge graph edges
DatabasesGeneCardsHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

LRP4 — Low Density Lipoprotein Receptor-Related Protein 4

gene · 1319 words

myasthenia-gravis

disease · 2044 words

LRP4 Protein - LDL Receptor-Related Protein 4

protein · 1091 words

CHRNG (Cholinergic Receptor Nicotinic Gamma Subunit)

gene · 911 words

LRP4 Protein

protein · 606 words

CHRNA1

gene · 544 words

Pathway Diagram

graph TD
    LRP4["<b>LRP4</b>"]
    Cancer{"Cancer"}
    LRP4 -->|"associated with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LRP4 -->|"associated with"| Neurodegeneration
    Cardiovascular{"Cardiovascular"}
    LRP4 -->|"associated with"| Cardiovascular
    Als{"Als"}
    LRP4 -->|"associated with"| Als
    Aging{"Aging"}
    LRP4 -->|"associated with"| Aging
    Hypertension{"Hypertension"}
    LRP4 -->|"associated with"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    LRP4 -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    LRP4 -->|"associated with"| Stroke
    Ms{"Ms"}
    LRP4 -->|"associated with"| Ms
    Heart_Failure{"Heart Failure"}
    LRP4 -->|"associated with"| Heart_Failure
    Ftd{"Ftd"}
    LRP4 -->|"associated with"| Ftd
    ALS{"ALS"}
    LRP4 -->|"associated with"| ALS
    LRP8["LRP8"]
    LRP8 -->|"associated with"| LRP4
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LRP4
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LRP4
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LRP4
    LRP1B["LRP1B"]
    LRP1B -->|"associated with"| LRP4
    PAH["PAH"]
    PAH -->|"associated with"| LRP4
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP4
    LDL["LDL"]
    LDL -->|"associated with"| LRP4
    STROKE["STROKE"]
    STROKE -->|"associated with"| LRP4
    REELIN["REELIN"]
    REELIN -->|"associated with"| LRP4
    AND["AND"]
    AND -->|"associated with"| LRP4
    AGING["AGING"]
    AGING -->|"associated with"| LRP4
    style LRP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

TargetRelationTypeStr
Cancerassociated_withdisease0.65
Neurodegenerationassociated_withdisease0.65
Cardiovascularassociated_withdisease0.65
Alsassociated_withdisease0.65
Agingassociated_withdisease0.65

Incoming (18)

SourceRelationTypeStr
LRP8associated_withgene0.60
LRP5associated_withgene0.60
LRP1associated_withgene0.60
LRP2associated_withgene0.60
LRP1Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found