Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LRP1B |
| Full Name | Low Density Lipoprotein Receptor-Related Protein 1B |
| Aliases | Page for LRP1B Protein |
| Chromosome | 2q22.1 |
| Protein Type | Protein |
| Function | is a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems. |
| Molecular Weight | 500 kDa |
| Amino Acids | 595 aa |
| Exons | 92 |
| Pathways | MAPK, PI3K, Wnt signaling |
| UniProt ID | Search UniProt |
| GeneCards | LRP1B |
| Human Protein Atlas | LRP1B |
| Feature | LRP1B |
| Amino acids | 4,595 |
| Associated Diseases | ALS, Aging, Atherosclerosis, Cancer, Cardiovascular |
| Interactions | PAH, APOE, WNT, CANCER, APOPTOSIS, PD-1 |
| KG Connections | 100 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LRP1B["<b>LRP1B</b>"]
Cancer{"Cancer"}
LRP1B -->|"associated with"| Cancer
Neurodegeneration{"Neurodegeneration"}
LRP1B -->|"associated with"| Neurodegeneration
Cardiovascular{"Cardiovascular"}
LRP1B -->|"associated with"| Cardiovascular
Als{"Als"}
LRP1B -->|"associated with"| Als
Aging{"Aging"}
LRP1B -->|"associated with"| Aging
Hypertension{"Hypertension"}
LRP1B -->|"associated with"| Hypertension
Atherosclerosis{"Atherosclerosis"}
LRP1B -->|"associated with"| Atherosclerosis
Stroke{"Stroke"}
LRP1B -->|"associated with"| Stroke
Ms{"Ms"}
LRP1B -->|"associated with"| Ms
Heart_Failure{"Heart Failure"}
LRP1B -->|"associated with"| Heart_Failure
Ftd{"Ftd"}
LRP1B -->|"associated with"| Ftd
ALS{"ALS"}
LRP1B -->|"associated with"| ALS
LRP8["LRP8"]
LRP8 -->|"associated with"| LRP1B
LRP5["LRP5"]
LRP5 -->|"associated with"| LRP1B
LRP1["LRP1"]
LRP1 -->|"associated with"| LRP1B
LRP2["LRP2"]
LRP2 -->|"associated with"| LRP1B
LDLR["LDLR"]
LDLR -->|"associated with"| LRP1B
LDL["LDL"]
LDL -->|"associated with"| LRP1B
STROKE["STROKE"]
STROKE -->|"associated with"| LRP1B
LRP4["LRP4"]
LRP4 -->|"associated with"| LRP1B
PAH["PAH"]
PAH -->|"associated with"| LRP1B
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"associated with"| LRP1B
CANCER["CANCER"]
CANCER -->|"associated with"| LRP1B
REELIN["REELIN"]
REELIN -->|"associated with"| LRP1B
style LRP1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Heart Failure | associated_with | disease | 0.65 |
| Ftd | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Hypertension | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| LRP4 | associated_with | gene | 0.60 |
| PAH | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LRP5 | associated_with | gene | 0.60 |
| LRP1 | associated_with | gene | 0.60 |
| LRP8 | associated_with | gene | 0.60 |
| LRP2 | associated_with | gene | 0.60 |
| RYR2 | associated_with | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| NCOR1 | associated_with | gene | 0.60 |
| ATRX | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| RB1 | associated_with | gene | 0.60 |
| TFE3 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| MUC16 | associated_with | gene | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| AGING | associated_with | gene | 0.60 |
| Lipid Metabolism | activates | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Oxidative Phosphorylation | therapeutic_target | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| LDL | associated_with | gene | 0.60 |
| Endothelial | associated_with | cell_type | 0.60 |
| Monocyte | associated_with | cell_type | 0.60 |
| TTN | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRP8 | associated_with | gene | 0.60 |
| LRP5 | associated_with | gene | 0.60 |
| LRP1 | associated_with | gene | 0.60 |
| LRP2 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LRP4 | associated_with | gene | 0.60 |
| PAH | associated_with | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| PAH | activates | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| RYR2 | associated_with | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| LDL | associated_with | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| TTN | associated_with | gene | 0.60 |
| APOER2 | associated_with | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| PD-1 | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| LDL | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||