gene

LRP1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections
0Hypotheses
0Analyses
50Outgoing
31Incoming

Summary

Gene: LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

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🧬 Gene Info
Gene SymbolLRP1B
Full NameLow Density Lipoprotein Receptor-Related Protein 1B
AliasesPage for LRP1B Protein
Chromosome2q22.1
Protein TypeProtein
Functionis a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight500 kDa
Amino Acids595 aa
Exons92
PathwaysMAPK, PI3K, Wnt signaling
UniProt IDSearch UniProt
GeneCardsLRP1B
Human Protein AtlasLRP1B
FeatureLRP1B
Amino acids4,595
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsPAH, APOE, WNT, CANCER, APOPTOSIS, PD-1
KG Connections100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: LRP1B — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

gene · 3338 words

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

gene · 1937 words

LDL Receptor Protein

protein · 1288 words

LRP1B Protein

protein · 884 words

LRP2 Protein (Megalin)

protein · 833 words

LRP1B Protein - LDL Receptor-Related Protein 1B

protein · 813 words

Pathway Diagram

graph TD
    LRP1B["<b>LRP1B</b>"]
    Cancer{"Cancer"}
    LRP1B -->|"associated with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LRP1B -->|"associated with"| Neurodegeneration
    Cardiovascular{"Cardiovascular"}
    LRP1B -->|"associated with"| Cardiovascular
    Als{"Als"}
    LRP1B -->|"associated with"| Als
    Aging{"Aging"}
    LRP1B -->|"associated with"| Aging
    Hypertension{"Hypertension"}
    LRP1B -->|"associated with"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    LRP1B -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    LRP1B -->|"associated with"| Stroke
    Ms{"Ms"}
    LRP1B -->|"associated with"| Ms
    Heart_Failure{"Heart Failure"}
    LRP1B -->|"associated with"| Heart_Failure
    Ftd{"Ftd"}
    LRP1B -->|"associated with"| Ftd
    ALS{"ALS"}
    LRP1B -->|"associated with"| ALS
    LRP8["LRP8"]
    LRP8 -->|"associated with"| LRP1B
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LRP1B
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LRP1B
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LRP1B
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP1B
    LDL["LDL"]
    LDL -->|"associated with"| LRP1B
    STROKE["STROKE"]
    STROKE -->|"associated with"| LRP1B
    LRP4["LRP4"]
    LRP4 -->|"associated with"| LRP1B
    PAH["PAH"]
    PAH -->|"associated with"| LRP1B
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| LRP1B
    CANCER["CANCER"]
    CANCER -->|"associated with"| LRP1B
    REELIN["REELIN"]
    REELIN -->|"associated with"| LRP1B
    style LRP1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

TargetRelationTypeStr
Cancerassociated_withdisease0.65
Neurodegenerationassociated_withdisease0.65
Cardiovascularassociated_withdisease0.65
Alsassociated_withdisease0.65
Agingassociated_withdisease0.65

Incoming (31)

SourceRelationTypeStr
LRP8associated_withgene0.60
LRP5associated_withgene0.60
LRP1associated_withgene0.60
LRP2associated_withgene0.60
LDLRassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found