Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL TRANSFER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MITOCHONDRIAL TRANSFER |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
graph TD
MITOCHONDRIAL_TRANSFER["MITOCHONDRIAL TRANSFER"]
MITOCHONDRIAL_TRANSFER -->|"regulates"| Osteoclastic_Lineage_Commitmen["Osteoclastic Lineage Commitment"]
MITOCHONDRIAL_TRANSFER -->|"regulates"| BONE_RESORPTION["BONE RESORPTION"]
MITOCHONDRIAL_TRANSFER -->|"involved_in"| Skeletal_Homeostasis["Skeletal Homeostasis"]
MITOCHONDRIAL_TRANSFER -->|"regulates"| Bone_Resorption["Bone Resorption"]
MITOCHONDRIAL_TRANSFER -->|"regulates"| Osteoclast_Differentiation["Osteoclast Differentiation"]
MITOCHONDRIAL_TRANSFER -.protects against.-> Osteoarthritis["Osteoarthritis"]
MITOCHONDRIAL_TRANSFER -->|"treats"| Parkinson_s_Disease["Parkinson's Disease"]
MIRO1["MIRO1"] -->|"regulates"| MITOCHONDRIAL_TRANSFER
Mesenchymal_Stromal_Cells["Mesenchymal Stromal Cells"] -->|"involved_in"| MITOCHONDRIAL_TRANSFER
RHOT1["RHOT1"] -->|"regulates"| MITOCHONDRIAL_TRANSFER
GJA1["GJA1"] -->|"mediates"| MITOCHONDRIAL_TRANSFER
GJA1_20k["GJA1-20k"] -->|"involved_in"| MITOCHONDRIAL_TRANSFER
Gja1_20K["Gja1-20K"] -->|"involved_in"| MITOCHONDRIAL_TRANSFER| Target | Relation | Type | Str |
|---|---|---|---|
| BONE RESORPTION | regulates | entity | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MIRO1 | regulates | entity | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial Transfer Pathway Enhancement | 0.443 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| CX43 hemichannel engineering enables size-selective mitochon | 0.415 | neurodegeneration | Mitochondrial transfer between astrocyte |
| GAP43-mediated tunneling nanotube stabilization enhances neu | 0.380 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Optogenetic Control of Mitochondrial Transfer Networks | 0.378 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
cell biology | 2026-04-12 | 2 hypotheses Top: 0.579
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] | Yao RQ, Ren C, Xia ZF, Yao YM | Autophagy | 2021 | 2 |
| Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060] | Xiong W, Su Y, Verkhratsky A, Yi C | Neuropharmacology | 2026 | 1 |
| Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567] | Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan | Nat Commun | 2025 | 1 |
| Miro1: A potential target for treating neurological disorders. [PMID:40403957] | Zeng L, Yang J, Zhang C, Zhu J, Zhong S, | Neuroscience | 2025 | 1 |
| Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955] | Domingues N, Ribeiro-Rodrigues T, Girão | Autophagy | 2024 | 1 |
| Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589] | Irwin RM, Thomas MA, Fahey MJ, Mayán MD, | Stem Cell Res Ther | 2024 | 1 |
| Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420] | Lisek M, Tomczak J, Boczek T, Zylinska L | Biomolecules | 2024 | 1 |
| Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020] | Ding P, Gao C, Zhou J, Mei J, Li G, Liu | Nat Commun | 2024 | 1 |
| Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260] | Maroto IB, Moreno E, Costas-Insua C, Mer | Neuropharmacology | 2023 | 1 |
| lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596] | Li P, Wang K, Yin J, Qi L, Hu H, Yang P, | Front Cardiovasc Med | 2022 | 1 |
| Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] | Boal AM, Risner ML, Cooper ML, Wareham L | Cells | 2021 | 1 |
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283] | König T, Nolte H, Aaltonen MJ, Tatsuta T | Nat Cell Biol | 2021 | 1 |
| Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222] | Ahmad T, Mukherjee S, Pattnaik B, Kumar | EMBO J | 2014 | 1 |
| Nerve growth cone motility. [PMID:2139335] | Lankford K, Cypher C, Letourneau P | Curr Opin Cell Biol | 1990 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609] | Yakati V, Rao SS | Biotechnol Bioeng | 2026 | 0 |
| The AP-1 transcription factors differentially regulate Cx43 expression in a ERK1 [PMID:41930557] | Basque A, Izichkis LS, Mellet C, Martin | Reprod Biol | 2026 | 0 |
| The synergistic effects of UV-328 and polystyrene microplastics on zebrafish emb [PMID:41771220] | Yang X, Liao X, Zhong L, Lin M, Zhang M | Aquat Toxicol | 2026 | 0 |