NDUFS8

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive gene page for NDUFS8, encoding a critical iron-sulfur subunit of mitochondrial Complex I, implicated in Parkinson's disease, Leigh syndrome, and other neurodegenerative disorders

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graph TD
    NDUFS8["<b>NDUFS8</b>"]
    Alzheimer{"Alzheimer"}
    NDUFS8 -->|"expressed in"| Alzheimer
    Cancer{"Cancer"}
    NDUFS8 -->|"expressed in"| Cancer
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NDUFS8 -->|"expressed in"| ALZHEIMER_S_DISEASE
    CYTOKINES["CYTOKINES"]
    NDUFS8 -->|"expressed in"| CYTOKINES
    LDLR["LDLR"]
    NDUFS8 -->|"expressed in"| LDLR
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    NDUFS8 -->|"expressed in"| ALZHEIMER_DISEASE
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    NDUFS8 -->|"expressed in"| MITOCHONDRIAL_DYSFUNCTION
    CLU["CLU"]
    NDUFS8 -->|"regulates"| CLU
    SPG7["SPG7"]
    NDUFS8 -->|"regulates"| SPG7
    MAPT["MAPT"]
    NDUFS8 -->|"regulates"| MAPT
    Epigenetic(["Epigenetic"])
    NDUFS8 -->|"expressed in"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    NDUFS8 -->|"expressed in"| Dna_Methylation
    ACE["ACE"]
    ACE -->|"expressed in"| NDUFS8
    PHGDH["PHGDH"]
    PHGDH -->|"biomarker for"| NDUFS8
    HK2["HK2"]
    HK2 -->|"biomarker for"| NDUFS8
    CANCER["CANCER"]
    CANCER -->|"expressed in"| NDUFS8
    SMAD3["SMAD3"]
    SMAD3 -->|"biomarker for"| NDUFS8
    style NDUFS8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0