Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFKB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NFKB2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, implicated in. Associated with Als, Alzheimer, Carcinoma. Connected to 28 entities in the SciDEX knowledge graph.
| Gene Symbol | NFKB2 |
| Full Name | Nuclear Factor Kappa B Subunit 2 |
| Aliases | p100, LYT10, NF-κB2 |
| Chromosome | 10q24.32 |
| Protein Family | NF-κB transcription factors |
| Protein Type | Transcription Factor |
| Function | NFKB2 encodes p100, which is processed to p52. |
| Molecular Weight | 100 kDa |
| Amino Acids | 900 aa |
| Pathways | Nfkb, NFKB, NF-κB, NF-κB Pathway, NF-κB Signaling |
| UniProt ID | Q12986 |
| NCBI Gene ID | 4791 |
| Ensembl ID | ENSG00000100908 |
| GeneCards | NFKB2 |
| Human Protein Atlas | NFKB2 |
| Associated Diseases | neurodegeneration |
| Interactions | CD8, CD4 |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NFKB2["<b>NFKB2</b>"]
Carcinoma{"Carcinoma"}
NFKB2 -->|"inhibits"| Carcinoma
Als{"Als"}
NFKB2 -->|"inhibits"| Als
Tumor{"Tumor"}
NFKB2 -->|"inhibits"| Tumor
CD8["CD8"]
NFKB2 -->|"inhibits"| CD8
Epigenetic(["Epigenetic"])
NFKB2 -->|"activates"| Epigenetic
Cholesterol(["Cholesterol"])
NFKB2 -->|"inhibits"| Cholesterol
neurodegeneration["neurodegeneration"]
NFKB2 -->|"implicated in"| neurodegeneration
CD4["CD4"]
CD4 -->|"inhibits"| NFKB2
style NFKB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| IL1B | regulates | gene | 0.87 |
| Carcinoma | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| CD8 | inhibits | gene | 0.60 |
| NOTCH2 | regulates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Cholesterol | inhibits | pathway | 0.60 |
| GENES | regulates | gene | 0.60 |
| ASTROCYTE | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| NEUROINFLAMMATION | regulates | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
| Notch | regulates | pathway | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||