Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CSF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 94 entities in the SciDEX knowledge graph.
| Gene Symbol | CSF1 |
| Chromosome | 1p13.3 |
| Function | is a disulfide-bonded homodimer of approximately 60 kDa. |
| Primary Expression | neurons[@wang2018] |
| Molecular Weight | 60 kDa |
| Amino Acids | 554 aa |
| Exons | 11 |
| Pathways | PI3K, MAPK |
| Ensembl ID | ENSG00000184371 |
| GeneCards | CSF1 |
| Human Protein Atlas | CSF1 |
| Isoform 1 (canonical) | 554 amino acids, secreted soluble protein |
| Isoform 2 | Truncated, membrane-bound form |
| Isoform 3 | Alternative start site variant |
| N-terminal signal peptide | Directs secretion |
| Associated Diseases | Melanoma, Tumor, multiple sclerosis |
| Interactions | BAX, DDX58, STAT1, BNIP3L, NEAT1, PPARG |
| KG Connections | 161 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CSF1["<b>CSF1</b>"]
Cancer{"Cancer"}
CSF1 -->|"activates"| Cancer
Als{"Als"}
CSF1 -->|"activates"| Als
Senescence{"Senescence"}
CSF1 -->|"therapeutic target"| Senescence
Glioblastoma{"Glioblastoma"}
CSF1 -->|"therapeutic target"| Glioblastoma
Tumor{"Tumor"}
CSF1 -->|"activates"| Tumor
Ms{"Ms"}
CSF1 -->|"activates"| Ms
Aging{"Aging"}
CSF1 -->|"activates"| Aging
Carcinoma{"Carcinoma"}
CSF1 -->|"activates"| Carcinoma
BAX["BAX"]
CSF1 -->|"activates"| BAX
DDX58["DDX58"]
CSF1 -->|"activates"| DDX58
STAT1["STAT1"]
CSF1 -->|"activates"| STAT1
BNIP3L["BNIP3L"]
CSF1 -->|"activates"| BNIP3L
STAT1 -->|"activates"| CSF1
DDX58 -->|"activates"| CSF1
BAX -->|"activates"| CSF1
AGING["AGING"]
AGING -->|"activates"| CSF1
SOX2["SOX2"]
SOX2 -->|"activates"| CSF1
ATF2["ATF2"]
ATF2 -->|"activates"| CSF1
HNRNPU["HNRNPU"]
HNRNPU -->|"activates"| CSF1
MYC["MYC"]
MYC -->|"activates"| CSF1
style CSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | mediates | process | 0.80 |
| Inflammation | regulates | disease | 0.75 |
| Neuroinflammation | regulates | disease | 0.75 |
| ASTROCYTE | regulates | gene | 0.70 |
| NEUROINFLAMMATION | regulates | gene | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| macrophages | expressed_in | cell_type | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Senescence | therapeutic_target | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Melanoma | associated_with | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Bacterial Infection | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Glioma | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Glioblastoma | regulates | disease | 0.65 |
| Pyroptosis | activates | disease | 0.65 |
| Ferroptosis | activates | disease | 0.65 |
| Necroptosis | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| BAX | activates | gene | 0.60 |
| DDX58 | activates | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| BNIP3L | activates | gene | 0.60 |
| NEAT1 | activates | gene | 0.60 |
| PPARG | activates | gene | 0.60 |
| CDK2 | activates | gene | 0.60 |
| CTCF | therapeutic_target | gene | 0.60 |
| EP300 | activates | gene | 0.60 |
| IGF2BP2 | activates | gene | 0.60 |
| CSF1R | therapeutic_target | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| TOMM20 | associated_with | gene | 0.60 |
| IL6ST | regulates | gene | 0.60 |
| FGFR1 | regulates | gene | 0.60 |
| NFKB2 | regulates | gene | 0.60 |
| NOTCH2 | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PHF2 | regulates | enzyme | 0.95 |
| STAT1 | activates | gene | 0.60 |
| DDX58 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| SOX2 | activates | gene | 0.60 |
| ATF2 | activates | gene | 0.60 |
| HNRNPU | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| ASC | associated_with | gene | 0.60 |
| AIM2 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| CTSB | associated_with | gene | 0.60 |
| ATP6V0D1 | associated_with | gene | 0.60 |
| NLRP3 | associated_with | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| LAMP1 | associated_with | gene | 0.60 |
| PYCARD | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| ATG14 | activates | gene | 0.60 |
| CASP1 | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| TNFRSF1A | regulates | gene | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| TLR | associated_with | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| PYROPTOSIS | activates | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| LCN2 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| OLIGODENDROCYTE | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| CCL2 | interacts_with | gene | 0.60 |
| CCL2 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming | 0.589 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||