gene

CSF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

161Connections
1Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

CSF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 94 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCSF1
Chromosome1p13.3
Functionis a disulfide-bonded homodimer of approximately 60 kDa.
Primary Expressionneurons[@wang2018]
Molecular Weight60 kDa
Amino Acids554 aa
Exons11
PathwaysPI3K, MAPK
Ensembl IDENSG00000184371
GeneCardsCSF1
Human Protein AtlasCSF1
Isoform 1 (canonical)554 amino acids, secreted soluble protein
Isoform 2Truncated, membrane-bound form
Isoform 3Alternative start site variant
N-terminal signal peptideDirects secretion
Associated DiseasesMelanoma, Tumor, multiple sclerosis
InteractionsBAX, DDX58, STAT1, BNIP3L, NEAT1, PPARG
KG Connections161 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

csf1

gene · 1653 words

Complement-Mediated Synapse Loss

mechanism · 3185 words

Microglia Activation Mechanism

mechanism · 3164 words

CSF1R Inhibitors for Parkinson's Disease

therapeutic · 3030 words

trem2-therapeutics

therapeutic · 2921 words

CSF1R-Targeted Microglia Therapy

idea · 2114 words

Pathway Diagram

graph TD
    CSF1["<b>CSF1</b>"]
    Cancer{"Cancer"}
    CSF1 -->|"activates"| Cancer
    Als{"Als"}
    CSF1 -->|"activates"| Als
    Senescence{"Senescence"}
    CSF1 -->|"therapeutic target"| Senescence
    Glioblastoma{"Glioblastoma"}
    CSF1 -->|"therapeutic target"| Glioblastoma
    Tumor{"Tumor"}
    CSF1 -->|"activates"| Tumor
    Ms{"Ms"}
    CSF1 -->|"activates"| Ms
    Aging{"Aging"}
    CSF1 -->|"activates"| Aging
    Carcinoma{"Carcinoma"}
    CSF1 -->|"activates"| Carcinoma
    BAX["BAX"]
    CSF1 -->|"activates"| BAX
    DDX58["DDX58"]
    CSF1 -->|"activates"| DDX58
    STAT1["STAT1"]
    CSF1 -->|"activates"| STAT1
    BNIP3L["BNIP3L"]
    CSF1 -->|"activates"| BNIP3L
    STAT1 -->|"activates"| CSF1
    DDX58 -->|"activates"| CSF1
    BAX -->|"activates"| CSF1
    AGING["AGING"]
    AGING -->|"activates"| CSF1
    SOX2["SOX2"]
    SOX2 -->|"activates"| CSF1
    ATF2["ATF2"]
    ATF2 -->|"activates"| CSF1
    HNRNPU["HNRNPU"]
    HNRNPU -->|"activates"| CSF1
    MYC["MYC"]
    MYC -->|"activates"| CSF1
    style CSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (109)

TargetRelationTypeStr
Ferroptosismediatesprocess0.80
Inflammationregulatesdisease0.75
Neuroinflammationregulatesdisease0.75
ASTROCYTEregulatesgene0.70
NEUROINFLAMMATIONregulatesgene0.70

Incoming (52)

SourceRelationTypeStr
PHF2regulatesenzyme0.95
STAT1activatesgene0.60
DDX58activatesgene0.60
BAXactivatesgene0.60
SOX2activatesgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming 0.589 neurodegeneration Gene expression changes in aging mouse b

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found