NRXN3

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRXN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NRXN3 is a gene implicated in neurodegeneration research. Key relationships include: protects against, inhibits, implicated in. Associated with Als, Inflammation, Neurodegeneration. Connected to 29 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    NRXN3["NRXN3"]
    ALS["ALS"]
    NEURODEGENERATION["Neurodegeneration"]
    NEUROINFLAMMATION["Neuroinflammation"]
    OXIDATIVE_STRESS["Oxidative Stress"]
    BDNF["BDNF"]
    SOD1["SOD1"]
    SOD2["SOD2"]
    NLGN2["NLGN2"]
    PSD95["PSD95"]
    PRKAA1["PRKAA1 (AMPK)"]
    PDHA1["PDHA1"]
    CYCS["CYCS (Cytochrome C)"]
    CREB["CREB"]
    SYNAPTIC_FUNCTION["Synaptic Function"]
    MITOCHONDRIAL_DYSFUNCTION["Mitochondrial Dysfunction"]
    
    NRXN3 -->|"protects against"| ALS
    NRXN3 -->|"protects against"| NEURODEGENERATION
    NRXN3 -->|"protects against"| NEUROINFLAMMATION
    NRXN3 -->|"inhibits"| OXIDATIVE_STRESS
    NRXN3 -->|"inhibits"| BDNF
    NRXN3 -->|"inhibits"| SOD1
    NRXN3 -->|"protects"| SOD2
    NRXN3 -->|"interacts with"| NLGN2
    NRXN3 -->|"protects"| PSD95
    NRXN3 -->|"inhibits"| PRKAA1
    NRXN3 -->|"inhibits"| PDHA1
    NRXN3 -->|"inhibits"| CYCS
    NRXN3 -->|"protects"| CREB
    
    NLGN2 -->|"maintains"| SYNAPTIC_FUNCTION
    PSD95 -->|"supports"| SYNAPTIC_FUNCTION
    PDHA1 -->|"contributes to"| MITOCHONDRIAL_DYSFUNCTION
    CYCS -->|"triggers"| MITOCHONDRIAL_DYSFUNCTION
    OXIDATIVE_STRESS -->|"promotes"| NEUROINFLAMMATION
    MITOCHONDRIAL_DYSFUNCTION -->|"leads to"| NEURODEGENERATION
    
    style NRXN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style SOD2 fill:#1b5e20
    style PSD95 fill:#1b5e20
    style CREB fill:#1b5e20
    style SYNAPTIC_FUNCTION fill:#1b5e20
    style ALS fill:#7d4200
    style NEURODEGENERATION fill:#7d4200
    style NEUROINFLAMMATION fill:#ef5350
    style OXIDATIVE_STRESS fill:#ef5350
    style MITOCHONDRIAL_DYSFUNCTION fill:#ef5350
    style BDNF fill:#4a1a6b
    style SOD1 fill:#4a1a6b
    style NLGN2 fill:#4a1a6b
    style PRKAA1 fill:#4a1a6b
    style PDHA1 fill:#4a1a6b
    style CYCS fill:#4a1a6b